Propofol Sedation Alters Perceptual and Cognitive Functions in Healthy Volunteers as Revealed by Functional Magnetic Resonance Imaging

Editor ’s PerspectiveWhat We Already Know about This TopicLoss of consciousness during anesthesia is associated with a loss of anterior –posterior connectivityHowever, during anesthesia local sensory cortex function may be preservedWhat This Article Tells Us That Is NewDuring propofol sedation, activation on functional magnetic resonance imaging in higher cognitive areas, such as semantic and phonologic processing, is abolished with deep sedation and only partially suppressed with light sedationActivation related to lower sensory processing continues with deep and light sedationBackground Elucidating networks underlying conscious perception is important to understanding the mechanisms of anesthesia and consciousness. Previous studies have observed changes associated with loss of consciousness primarily using resting paradigms. The authors focused on the effects of sedation on specific cognitive systems using task-based functional magnetic resonance imaging. The authors hypothesized deepening sedation would degrade semantic more than perceptual discrimination.Methods Discrimination of pure tones and familiar names were studied in 13 volunteers during wakefulness and propofol sedation targeted to light and deep sedation. Contrasts highlighted specific cognitive systems: auditory/motor (tonesvs. fixation), phonology (unfamiliar namesvs. tones), and semantics (familiarvs. unfamiliar names), and were performed across sedation conditions, followed by region of interest ...
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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This article is protected by copyright. All rights reserved. PMID: 31283078 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research
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