Preadmission Statin Use and 90-day Mortality in the Critically Ill A Retrospective Association Study

This study aimed to examine the association between preadmission statin use and 90-day mortality in critically ill patients and to investigate whether this association differed according to statin type and dose. We hypothesized that preadmission statin use was associated with lower 90-day mortality.Methods This retrospective cohort study analyzed the medical records of all adult patients admitted to the intensive care unit in a single tertiary academic hospital between January 2012 and December 2017. Data including preadmission statin use, statin subtype, and daily dosage were collected, and the associations between these variables and 90-day mortality after intensive care unit admission were examined. The primary endpoint was 90-day mortality.Results A total of 24,928 patients (7,396 statin users and 17,532 non –statin users) were included. After propensity score matching, 5,354 statin users and 7,758 non–statin users were finally included. The 90-day mortality rate was significantly higher in non–statin users (918 of 7,758; 11.8%) than in statin users (455 of 5,354; 8.5%;P
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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nn J Abstract Because of new surgical techniques, advanced monitoring modalities and improvements in perioperative care, perioperative mortality and morbidity have been significantly reduced in the last decades; however, patients still suffer from high perioperative mortality and morbidity, especially those with pre-existing cardiovascular diseases. Not only perioperative myocardial infarction but also myocardial injury after non-cardiac surgery, which presents without clinical symptoms, is associated with an adverse outcome. Patients at risk require particular interdisciplinary attention throughout the perioperat...
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic an...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Ahmed Mohamed Elhfnawy1*, Peter U. Heuschmann2, Mirko Pham3†, Jens Volkmann1† and Felix Fluri1,4 1Department of Neurology, University Hospital Würzburg, Würzburg, Germany 2Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany 3Institute of Diagnostic and Interventional Neuroradiology, University Hospital of Würzburg, Würzburg, Germany 4Department of Neurology, Kantonssptial St. Gallen, St. Gallen, Switzerland Background and Purpose: Internal carotid artery stenosis (ICAS)≥70% is a leading cause of ischemic cerebrovascular event...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 5 April 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Shaun McMahon, Rachael L. BirdAbstractPatients undergoing major vascular surgery are high risk for myocardial infarction, renal failure, respiratory complications and death. Invasive procedures confer greater risk of complication, with patients undergoing open aortic surgery being at highest risk. Endovascular procedures are less invasive, yet not devoid of potentially serious complications. Reduction of myocardial oxygen demand is key: stabilizing cardiovascular parameters, maintaining normothermia, adequate volume re...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Duchenne muscular dystrophy (DMD), is the most common and severe neuromuscular disease affecting skeletal and cardiac muscle. Here, we showed that simvastatin both reversed pre ‐existing cardiac dysfunction and prevented its development during long‐term treatment of dystrophic mice. Simvastatin also prevented the progression of dystrophic cardiac fibrosis. Together, these findings indicate that simvastatin markedly improves cardiac health and function in dystrophic mic e, and therefore may provide a novel approach for treating cardiomyopathy in DMD patients. AbstractDuchenne muscular dystrophy (DMD), caused by absence ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A 73-year-old woman was referred for an elective aortic valve replacement for severe aortic stenosis. She had preserved biventricular function, mild left ventricular hypertrophy, and no significant coronary artery disease. From her medical history, she had dyslipidemia treated with statins and idiopathic normal pressure hydrocephalus (iNPH) awaiting shunt placement (Figure 1, Figure 2). She was experiencing only mild iNPH-related symptoms, namely urinary incontinence, gait disturbances, and dementia, and she had been following up regularly with a neurologist.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the manuscript published by Oh et al [1] which intended to determine role of peri-operative statin therapy in reducing incidence of post-operative delirium (POD) after unilateral total knee arthroplasty (TKA) under spinal anaesthesia. The authors found that continuous use of statins, specifically simvastatin and atorvastatin, during the peri-operative period, was associated with a decreased risk of developing POD after TKA under spinal anaesthesia. It was an interesting and novel study to evaluate a pharmacological intervention for prevention of POD after TKA, a complication which adversely affe...
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
The relationship between statin use and incidence of postoperative delirium (POD) is controversial. We investigated the association between perioperative statin use and occurrence of delirium after total knee arthroplasty (TKA) under spinal anesthesia.
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
This study suggests that oral statin therapy may be a new approach for patients with autoimmune pulmonary alveolar proteinosis.AUTHORSThe study ’s co-senior authors are Dr. Elizabeth Tarling of UCLA and Dr. Bruce Trapnell of Children’s Hospital Medical Center of Cincinnati, Ohio. Other authors are listed in the journal article.JOURNALThe study was  published in the journal Nature Communications. FUNDINGThe National Institutes of Health funded the research.Learn more about the  cardiovascular research theme at UCLA. 
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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