Skewed lymphocyte subpopulations and associated phenotypes in patients with mastocytosis

ConclusionsSeveral circulating lymphocyte subpopulations in patients with ISM were significantly different when compared to healthy controls; and in specific lymphocyte subsets, this lymphocyte skewing correlated with clinical observations including osteoporosis and autoimmune disease. These data suggest the need for further studies on abnormalities in lymphocyte subsets and the attendant clinical consequences in both mast cell proliferative and activation disorders.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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ConclusionRapid and accurate diagnosis of A-AIH may be difficult. However, timely start of immunosuppressive therapy improves prognosis and decreases number of indicated liver transplantations in children with AIH.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
This study demonstrates that, despite current monitoring approaches, contaminated and adulterated products are still reaching the consumer. We suggest that a better solution is stronger pre-market evaluation, using techniques such as that outlined in this study.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 23 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Sneha Suresh, Harjit Dadi, Brenda Reid, Linda Vong, Dennis E. Bulman, Chaim M. Roifman
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we investigated the protective effects of geniposide on dexamethasone (DEX)-induced osteogenic inhibition in MC3T3-E1 cells. The results showed that there was no obvious toxicity on MC3T3-E1 cells when geniposide was used at the doses ranging from 1 to 75 μM. In DEX-treated MC3T3-E1 cells, geniposide promoted the alkaline phosphatase (ALP) activity and the mineralization. In addition, geniposide also significantly increased the mRNA and protein expression of osteopontin (OPN), Runt-related transcription factor 2 (Runx2), and Osterix (Osx) in DEX-treated MC3T3-E1 cells. Furthermore, geniposide activated ER...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: March 2019Source: Advances in Medical Sciences, Volume 64, Issue 1Author(s): Joanna Renke, Sabina Kędzierska-Mieszkowska, Magdalena Lange, Bogusław Nedoszytko, Eliza Wasilewska, Anna Liberek, Marcin Renke, Marek Niedoszytko, Jacek Witkowski, Joanna Skórko-Glonek, Barbara LipińskaAbstractThe role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast ...
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
ska B Abstract The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Mastocytosis is a heterogeneous group of disorders characterized by accumulation of MC in one or more organs. There...
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
AbstractRheumatoid arthritis (RA) is a chronic and progressive autoimmune disease more common in women than men (3:1). Although sex-based differences may play a complex role in promoting an autoimmune dysfunction, to date the comprehensive knowledge of the link between sex and RA is still partially lacking. Furthermore, males and females have been demonstrated to differently deal with their chronic pathologies, modifying the perceived sex-based burden of disease. Gender medicine is a newly approach focusing on the impact of gender differences on human physiology, pathophysiology, and clinical features of diseases, analyzin...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsMechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic‐pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C‐reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness. Clinical RelevanceA good patient–provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antide...
Source: Journal of Nursing Scholarship - Category: Nursing Authors: Tags: CLINICAL SCHOLARSHIP Source Type: research
ConclusionsMechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic‐pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C‐reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness. Clinical RelevanceA good patient–provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antide...
Source: Journal of Nursing Scholarship - Category: Nursing Authors: Tags: CLINICAL SCHOLARSHIP Source Type: research
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