Maternal and paternal atopic dermatitis and risk of atopic dermatitis during early infancy in girls and boys

Publication date: Available online 15 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kim M.A Endre, Eva Maria Rehbinder, Karin Lødrup Carlsen, Kai-Håkon Carlsen, Petter Gjersvik, Gunilla Hedlin, Christine M. Jonassen, Marissa LeBlanc, Björn Nordlund, Håvard O. Skjerven, Anne Cathrine Staff, Cilla Söderhäll, Riyas Vettukattil, Linn Landrø, study group, Anna Asarnoj, Karen Eline S. Bains, Monica H. Carlsen, Oda C. Lødrup Carlsen, Peder A. Granlund, Berit Granum
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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This study evaluated nemolizumab plus topical corticosteroids in patients with AD and severe pruritus and found a significant effect on cutaneous signs of AD (by EASI and IGA), plus a rapid reduction of pruritus.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
A landmark study showed that early peanut introduction in high-risk infants, defined as infants with moderate to severe atopic dermatitis or egg allergy, reduced the risk of developing peanut allergy. Since this trial, many international societies have updated feeding guidelines to promote early introduction of peanut, usually around 6  months of age. Implementing these guidelines on a national and international level has been challenging. Furthermore, there is confusion if allergy testing is needed before peanut introduction in high-risk infants. Despite these challenges, the data are promising, that implantation of ...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
Background: Pruritus, or itch, is associated with a wide variety of conditions, including skin and medical disorders, allergies and infections, and exposure to some medications. In many of these conditions, such as atopic dermatitis, the intense pruritus and associated scratching can result in exacerbation of the disease and a reduced quality of life. The itching sensation is transmitted through afferent C-fibers. Sodium channels play a key role in the transmission process. Indeed, topical local anesthetics, which block sodium channels and are used to treat itch, generally have a short duration of action, and importantly, ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Eyelid dermatitis is a frequent reason for consultation in dermatology and allergic contact dermatitis is the most frequent underlying cause in patients referred to study with patch testing.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease, with a prevalence of 1-3% of the adult population. Usually begins in early childhood, progresses with a recurrent course before disappearing at puberty, and may persist to adulthood or present de novo during this period. It is frequently associated with elevated levels of serum IgE, individual or family history of type I allergies, allergic rhinitis and asthma. The therapeutic approach in adult AD patients can be frankly complicated beyond topical treatments, as phototherapy and/or systemic therapies often do not guarantee adequate c...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
The objectives of our study were to (1) establish the prevalence of hypersensitivity to components of knee prostheses in patients referred to our contact dermatitis clinic, (2) determine if patients with post-surgery dermatitis have become sensitized, and (3) describe the outcome of patients with and without hypersensitivity. We reviewed the charts of patients referred from 2007 to 2018 and extracted demographic information, date, type, and site of implant, clinical presentation, and results of patch testing (PT) or lymphocyte transformation tests (LTT). We called most patients to gather data such as clinical outcome, natu...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Alexandra Leonard, Jingya Wang, Li Yu, Hao Liu, Yeriel Estrada, Lydia Greenlees, Roderick McPhee, Alexey Ruzin, Emma Guttman-Yassky, Michael D. HowellAbstractBackgroundAtopic dermatitis (AD) is a chronic inflammatory disease with significant local and systemic inflammation and barrier disruption. AD is associated with increased risk of allergen sensitization and skin colonization by Staphylococcus aureus. The heterogeneity of AD is unknown, and its complexity suggests its subdivision into several e...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Abstract Limonene is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to limonene was considered rare because positive patch tests to it were infrequently observed. In recent years, however, it has been demonstrated that exposure of limonene to oxygen (air) results in the formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound. By routine testing of patients suspected of contact dermatitis with hydroperoxides of limonene, high frequencies of positive reactions were found, indicating that thes...
Source: Dermatitis - Category: Dermatology Authors: Tags: Dermatitis Source Type: research
This article gives an overview of fragrance allergy. The following subjects are discussed: composition of perfumes, contact with fragrances, diagnosing fragrance allergy, frequency of allergy, clinical picture of allergic contact dermatitis, culprit products, occupational contact dermatitis, and other adverse effects of fragrances. For diagnosing fragrance sensitization, personal products and a fragrance series may need to be tested in addition to the baseline series. In the general adult population, up to 4.5% may be allergic to fragrance materials, and in consecutive patients patch tested for suspected contact dermatitis...
Source: Dermatitis - Category: Dermatology Authors: Tags: Dermatitis Source Type: research
Abstract Identification of the etiological chemical agent(s) associated with a case(s) of allergic contact dermatitis (ACD) is important for both patient management and public health surveillance. Traditional patch testing can identify chemical allergens to which the patient is allergic. Confirmation of allergen presence in the causative ACD-associated material is presently dependent on labeling information, which may not list the allergenic chemical on the product label or safety data sheet. Dermatologists have expressed concern over the lack of laboratory support for chemical allergen identification and possibly...
Source: Dermatitis - Category: Dermatology Authors: Tags: Dermatitis Source Type: research
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