Malignant hyperthermia with RYR1 novel missense mutation.
This article is protected by copyright. All rights reserved. PMID: 31304636 [PubMed - as supplied by publisher]
In the original publication, in Abstract, the second sentence of Results has been incorrectly published as.
Contributors : Louise Y Fong ; Cristian Taccioli ; Alexey Palamarchuk ; Guidantonio M Tagliazucchi ; Ruiyan Jing ; Karl J Smalley ; Sili Fan ; Joseph Altemus ; Oliver Fiehn ; Kay Huebner ; John L Farber ; Carlo M CroceSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTranscriptomics analyses in these Zn-deficient rats revealed the molecular basis of ESCC abrogation by miR-31 knockout: Egln3, a negative regulator of NF-FB, was shown to be a direct miR-31 target; miR-31 inhibition/deletion resulted in suppression of miR-31-associated-EGLN3-NF-KB controlled inflammatory pathways.
ConclusionsEndoscopists should be aware that SMTs or erosions, even those smaller than 10 mm, can indicate local recurrence after complete response to definitive chemoradiotherapy. Follow-up endoscopy should be performed within 1–2 months if findings suggestive of local recurrence are observed on prior endoscopy, even when biopsy results are negative.
In conclusion, INFc is an independent risk factor for lymph node metastasis and an independent inferior prognostic factor for stage T1 ESCC. Furthermore, INFc is associated with immunosuppression, and the combination of the INF and TILs is useful for the risk stratification of prognosis.
CONCLUSIONS Our analysis is the first to show that SPP1 and FN1 might work as biological markers of progression and prognosis in esophageal carcinoma (ESCA). PMID: 32208405 [PubMed - in process]
CONCLUSION: Increase of HMGB1 levels in tumor cells or plasma plays a crucial role in the malignant potential of ESCC. Intracellular and extracellular HMGB1 may be a therapeutic target in ESCC. PMID: 32221734 [PubMed - as supplied by publisher]
CONCLUSIONS: Abrogation of G2/M checkpoint by targeting Wee1 kinase with AZD1775 sensitizes ESCA cells to radiotherapy in vitro and in mouse xenografts. Our findings suggest that inhibition of Wee1 by AZD1775 is an effective strategy for radiosensitization in esophageal cancer and warrants clinical testing. PMID: 32220892 [PubMed - as supplied by publisher]
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. Due to its high morbidity and mortality rates, it is urgent to find a molecular target that contributes to esophageal c...
CONCLUSIONS MiR-340-5p functioned as an oncogene of ESCC by directly binding and repressing the expression of PIK3C3. PMID: 32207410 [PubMed - in process]