Down regulation of type 3 deiodinase in the hypothalamus during inflammation.

CONCLUSIONS: We conclude that the inflammation induced D3 decrease in the hypothalamus is mediated by the inflammatory pathways NF-κB and AP-1, but not TRα1. Furthermore, the observed decrease modulates intracellular T3 concentrations. Our results suggest a concerted action of inflammatory modulators to regulate both hypothalamic D2 and D3 activity in order to increase the local TH concentrations. PMID: 31303139 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31303139?dopt=Abstract

Source: Thyroid : official journal of the American Thyroid Association - July 17, 2019 Category: Endocrinology Tags: Thyroid Source Type: research