Network meta-analysis: Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction

Source: European urology Area: News Phosphodiesterase type 5 inhibitors (PDE5-Is) including sildenafil, tadalafil, and vardenafil are currently the first-line therapy for erectile dysfunction (ED). However there are few comparative data investigating the effects of different classes of oral PDE5-Is.   To address this gap in knowledge a systematic search was performed in PubMed, Cochrane Library, and Embase to identify randomised controlled trials (RCTs) that compared different PDE5-Is (sildenafil, tadalafil, vardenafil, udenafil, mirodenafil, and avanafil) or PDE5-Is with a placebo for ED. The authors used network meta-analysis, i.e. they compared multiple treatments using both direct comparisons of interventions within RCTs and indirect comparisons across trials based on a common comparator. The primary outcomes for this study were the Global Assessment Questionnaire question 1 (GAQ-1), and change from baseline to study end in the International Index of Erectile Function-Erectile Function domain score ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news

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THURSDAY, March 26, 2020 -- Until the discovery of Viagra, men with erectile dysfunction were largely left with the impression that their sexual problems were all in their head. That might still be somewhat true, even in this age of little blue...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Resistance toward current and new classes of anti-tuberculosis (anti-TB) antibiotics are rapidly emerging; thus, innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches for shortening therapy regimens without inducing drug resistance. Development of new TB drugs is lengthy and expensive, and success is not guaranteed; thus, alternatives are needed. Repurposed drugs have already passed Food and Drug Administration (FDA) as well as European Medicines Agency (EMA) safety requirements and may only need to prove efficacy against Mycobacterium tuberculosis (M.tb). Pho...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Corona G, Rastrelli G, Isidori AM, Pivonello R, Bettocchi C, Reisman Y, Sforza A, Maggi M Abstract Introduction: A large body of evidence has clearly documented that erectile dysfunction (ED) represents not only a complication of cardiovascular (CV) diseases (CVD) but often an early sign of forthcoming CVD.Areas covered: All the available data from meta-analyses evaluating the association between ED and CV risk were collected and discussed. Similarly, all available meta-analyses investigating the significance of ED as a possible early marker for major adverse cardiovascular events (MACE) were analyzed. In ...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
ConclusionWe observed significant association between the low-IIEF-5 and high-IIEF-5 groups inAlistipes andClostoridium XVIII. Further study is necessary to access the causal relationship between the gut microbiome and ED.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Perret C, Van Biesen D, Strupler M, Pit-Grosheide P, Vanlandewijck Y Abstract PURPOSE: Ingestion of sildenafil citrate has performance-enhancing effects at high altitudes above 3800 m in able-bodied individuals. It is unknown whether it can improve the performance of athletes with spinal cord injury (SCI) at moderate altitudes (
Source: International Journal of Sports Physiology and Performance - Category: Sports Medicine Tags: Int J Sports Physiol Perform Source Type: research
ConclusionDKK3 restored cavernous vascular integrity and improved erectile function in diabetic mice. Therapeutic cavernous angiogenesis by use of DKK3 will be a promising therapeutic strategy to treat diabetic erectile dysfunction.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, many MS drugs produce erectile dysfunction, etc.). Appropriate symptomatic therapy is an unmet need. Several important functions/symptoms (muscle tone, sleep, bladder, pain) are mediated, in great part, in the brainstem. Cannabinoid receptors are distributed throughout the CNS irregularly: There is an accumula...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
I understand that height is associated with better cardiovascular health in some studies. Does this imply lower incidence of ED among taller men? Thanks!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: MCAT Study Question Q&A Source Type: forums
Authors: Ceyhun G, Erbay G Abstract BACKGROUND: The aim of this study was to investigate the association between left ventricular diastolic dysfunction (LVDD) and erectile dysfunction (ED) without overt cardiovascular disease. METHODS: A total of 80 patients with LVDD and without a history of coronary artery disease were compared with 80 age- and gender-matched healthy controls. The International Index of Erectile Function Questionnaire (IIEF-5) was used to diagnose and grade ED. LVDD and its relation with ED severity were assessed. RESULTS: The mean age, body mass index, total testosterone, low- and high-d...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
AbstractBackgroundSexual dysfunction (SD) is a common, yet under-reported, non-motor symptom (NMS) of Parkinson ’s disease (PD). The present study investigated the sexual functions in PD male patients, its correlation with motor and other NMSs, and their impact on health-related quality of life (HRQoL).MethodsThe sexual functions of 40 PD male patients were assessed using the International Index of Erectile Function (IIEF) and compared to 25 healthy age-matched controls. Patients were evaluated using the NMS Scale (NMSS) and the Arabic version of the Parkinson ’s-Disease Questionnaire (PDQ-39). We compared the ...
Source: Neurological Sciences - Category: Neurology Source Type: research
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