Impact of Complications After Cardiac Surgery on One-Year Patient Reported Outcomes

Publication date: Available online 16 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): J. Hunter Mehaffey, Robert B. Hawkins, Eric J. Charles, Irving L. Kron, Gorav Ailawadi, John A. Kern, Mark E. Roeser, Benjamin Kozower, Nicholas R. TemanAbstractBackgroundCurrently, reporting on cardiac surgical outcomes focus on a patient’s status at 30 days and lack long-term meaningful data. The purpose of this study was to determine the impact of complications after cardiac surgery on patient-reported outcomes (PRO) at one-year after surgery.MethodsAll patients undergoing cardiac surgery at an academic institution (2014-2015) were contacted one year after surgery to obtain vital status, location and PRO using the validated Patient-Reported Outcomes Measurement Information System (NIH-PROMIS). Records were merged with Society of Thoracic Surgeons (STS) data and multivariate linear regression evaluated the risk-adjusted effects of complications on one-year PRO.ResultsA total of 782 eligible patients underwent cardiac surgery with PRO data available for 91% of patients alive at 1 year (648/716). Mean PROMIS scores were: global physical health (GPH)=48.8±10.2, global mental health (GMH)=51.3±9.5, and physical functioning (PF)=45.5±10.2 (reference score for general adult population=50±10). Occurrence of a STS major morbidity (prolonged ventilation, renal failure, reoperation, stroke, deep sternal wound infection) significantly reduced one-year PRO (...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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Publication date: January 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 1Author(s): J. Hunter Mehaffey, Robert B. Hawkins, Eric J. Charles, Irving L. Kron, Gorav Ailawadi, John A. Kern, Mark E. Roeser, Benjamin Kozower, Nicholas R. TemanBackgroundCurrent reporting on cardiac surgical outcomes focuses on a patient’s status at 30 days and lacks long-term meaningful data. The purpose of this study was to determine the impact of complications after cardiac operation on patient-reported outcomes (PROs) at 1 year after surgery.MethodsAll patients undergoing cardiac operation at an academic institution (2014...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion: The IIT did not improve the morbidity and mortality in our patients undergoing coronary artery bypass grafting.
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
ConclusionsEndobronchial administration of ε-aminocaproic acid during bronchoscopy may be a safe and efficacious option in the treatment and prevention of pulmonary bleeding. Further studies are necessary to better define ε-aminocaproic acid's safety profile, optimal routes of administration, and comparative effectiveness to tranexamic acid.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Authors: Mureddu GF, Greco C, Rosato S, D'Errigo P, De Luca L, Badoni G, Faggiano P, Seccareccia F Abstract The risk of recurrent events among survivors of acute myocardial infarction (AMI) is understudied. The aim of this analysis was to investigate the role of residual high thrombotic risk (HTR) as a predictor of recurrent in-hospital events after AMI. This retrospective cohort study included 186,646 patients admitted with AMI from 2009 to 2010 in all Italian hospitals who were alive 30 days after the index event. HTR was defined as at least one of the following in the 5 years preceding AMI: previous myocardial i...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
CONCLUSIONS: This review identified only nine studies, with insufficient data for all pharmacological interventions for analysis. The available evidence is very uncertain regarding the efficacy or harm from pharmacological interventions used to treat pain related to sickle cell VOC in adults. This area could benefit most from more high quality, certain evidence, as well as the establishment of suitable registries which record interventions and outcomes for this group of people. PMID: 31742673 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: Preoperative coronary angiography in patients affected by infective endocarditis provides relevant information in a significant proportion of patients and can be performed safely. PMID: 31734140 [PubMed - as supplied by publisher]
Source: Archives of Cardiovascular Diseases - Category: Cardiology Authors: Tags: Arch Cardiovasc Dis Source Type: research
In conclusion, preoperative use of mammography was strongly associated with fewer perioperative complications and less in-hospital mortality after major surgeries. The evidence provided by this study justifies the implementation of preoperative health checks in clinical practice.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionGraphical tool monitoring of risk ‐adjusted 30‐day mortality and morbidity following cardiac surgery is feasible and allows detection of underperformance and implementation of changes in clinical practice.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractIntroductionThe outcomes of transfemoral (TF) compared with transapical (TA) access for transcatheter aortic valve replacement (TAVR) in diabetics are unknown.MethodsWe queried the NIS database (2011 –2014) to identify diabetics who underwent TAVR. We performed a propensity matching analysis comparing TF-TAVR versus TA-TAVR.ResultsThe analysis included 14.555 diabetics who underwent TAVR. After matching, in-hospital mortality was not different between TF-TAVR and TA-TAVR. (3.5 vs. 4.4%,p = 0.11). TF-TAVR was associated with lower rates of cardiogenic shock (2.7 vs. 4.7%,p = 0.02), ...
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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