Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.

Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid. Eur Arch Psychiatry Clin Neurosci. 2019 Jul 13;: Authors: Johansson V, Erhardt S, Engberg G, Kegel M, Bhat M, Schwieler L, Blennow K, Zetterberg H, Cannon TD, Wetterberg L, Hultman CM, Landén M Abstract Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. PMID: 31302732 [PubMed - as supplied by publisher]
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

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