Crystal structure of the inhibitor-free form of the serine protease kallikrein-4

In this study, an inhibitor-free form of KLK4 was crystallized. The crystals obtained belonged to space group P1, contained four molecules in the asymmetric unit and diffracted to 1.64   Å resolution. Interestingly, a nonstandard rotamer of the specificity-determining residue Asp189 was observed in all chains. This model will provide a useful unliganded structure for the future structure-guided design of KLK4 inhibitors.
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: kallikrein-related peptidase 4 KLK4 apo structure unliganded research communications Source Type: research

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Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): B. Choi, H. Jung, B. Yu, H. Choi, J. Lee, D. Kim
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Conditions:   Prostate Cancer;   Treatment Interventions:   Procedure: Focal therapy(Irreversible Electroporation);   Procedure: Radical prostatectomy Sponsor:   Shanghai East Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed to evaluate whether IRE combining indoleamine 2,3-dioxygenase inhibitor (IDOi, Epacadostat) loaded iron oxide nanocarriers (IDOi-INCs) can serve as a magnetic resonance imaging (MRI) –guided local ablation strategy for enhancing prostate cancer immunotherapy.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 12 Source Type: research
The purpose of this study is to assess clinical outcomes of prostatic artery embolization (PAE) in men with localized prostate cancer (PCa) and lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 7 Source Type: research
We aimed to update the diagnostic yield of in-bore 3Tesla magnetic-resonance-guided biopsy (3T-MRGB) for prostate cancer (PCa) detection based on the assessment by recently described Prostate Imaging Reporting and Data System version 2.1(PIRADSv2.1).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 12 Source Type: research
We report 12-month outcomes from the TULSA-PRO Ablation Clinical Trial (TACT) pivotal study.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 37 Source Type: research
To evaluate the changes of 3 Tesla (3T) mpMRI and prostate-specific antigen (PSA) parameters before and during multiple time points after whole gland prostate cancer (PCa) treatment using MRI-guided directional transurethral ultrasound ablation (TULSA)
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 37 Source Type: research
Focal laser ablation (FLA) for prostate cancer is usually performed in an MRI gantry, but can be performed outside MRI with transrectal ultrasound (TRUS) –MRI fusion. Relative costs were compared between the two approaches.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
To evaluate the potential of sequential MR image –guided local immune checkpoint blockade immunotherapy using multifunctional carriers after a prechemotherapy in prostate cancer (PC).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Traditional Poster Source Type: research
For localized prostate cancer, a hypofractionated radiotherapy regimen that cuts treatment time in half continues to have noninferior efficacy long-term relative to a conventional radiotherapy regimen.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
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