AAV2/9-mediated overexpression of MIF inhibits SOD1 misfolding, delays disease onset, and extends survival in mouse models of ALS [Neuroscience]

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of upper and lower motor neurons. Transgenic mice that overexpress mutant SOD1 develop paralysis and accumulate misfolded SOD1 onto the cytoplasmic faces of intracellular organelles, including mitochondria and endoplasmic reticulum (ER). Recently, macrophage...

http://www.pnas.org/content/116/29/14755.short?rss=1

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Marcel F. Leyton-Jaimes, Joy Kahn, Adrian Israelson Tags: Biological Sciences Source Type: research