Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells [Cell Biology]

Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of Drosophila genes that are insulin-responsive and also regulate nucleolus size, we enriched for Myc target genes required for cellular biosynthesis. Among these, we identified the aminoacyl tRNA synthetases (aaRSs) as essential mediators of...

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Jonathan Zirin, Xiaochun Ni, Laura M. Sack, Donghui Yang-Zhou, Yanhui Hu, Roderick Brathwaite, Martha L. Bulyk, Stephen J. Elledge, Norbert Perrimon Tags: Biological Sciences Source Type: research