Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci [Microbiology]

Global growth in antibiotic resistance is a major social problem. A high level of resistance to fluoroquinolones requires the concurrent presence of at least 3 mutations in the target proteins—2 in DNA gyrase (GyrA) and 1 in topoisomerase IV (ParC), which occur in a stepwise manner. In the Escherichia coli...

http://www.pnas.org/content/116/29/14740.short?rss=1

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Veronika Tchesnokova, Matthew Radey, Sujay Chattopadhyay, Lydia Larson, Jamie Lee Weaver, Dagmara Kisiela, Evgeni V. Sokurenko Tags: PNAS Plus Source Type: research