Paf1C regulates RNA polymerase II progression by modulating elongation rate [Biochemistry]

Elongation factor Paf1C regulates several stages of the RNA polymerase II (Pol II) transcription cycle, although it is unclear how it modulates Pol II distribution and progression in mammalian cells. We found that conditional ablation of Paf1 resulted in the accumulation of unphosphorylated and Ser5 phosphorylated Pol II around promoter-proximal...

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Liming Hou, Yating Wang, Yu Liu, Nan Zhang, Ilya Shamovsky, Evgeny Nudler, Bin Tian, Brian David Dynlacht Tags: PNAS Plus Source Type: research