Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function [Biochemistry]

Androgen receptor (AR) is a ligand-activated transcription factor and a key driver of prostate cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated gene expression provides new opportunities for therapeutic intervention. Poly(ADP-ribose) Polymerase (PARP) is a family of enzymes, which posttranslationally modify a range of proteins and regulate many...

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Bin Gui, Fu Gui, Tomoaki Takai, Chao Feng, Xiao Bai, Ladan Fazli, Xuesen Dong, Shuai Liu, Xiaofeng Zhang, Wei Zhang, Adam S. Kibel, Li Jia Tags: PNAS Plus Source Type: research