Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR [Applied Biological Sciences]

Light-sensitive G protein-coupled receptors (GPCRs)—rhodopsins—absorb photons to isomerize their covalently bound retinal, triggering conformational changes that result in downstream signaling cascades. Monostable rhodopsins release retinal upon isomerization as opposed to the retinal in bistable rhodopsins that “reisomerize” upon absorption of a second photon. Understanding the mechanistic differences between these light-sensitive...

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Niranȷan Varma, Eshita Mutt, Jonas Muhle, Valerie Panneels, Akihisa Terakita, Xavier Deupi, Przemyslaw Nogly, Gebhard F. X. Schertler, Elena Lesca Tags: PNAS Plus Source Type: research