Impact of 17 β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.

Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration. Cell Mol Life Sci. 2019 Jul 13;: Authors: Tsachaki M, Strauss P, Dunkel A, Navrátilová H, Mladenovic N, Odermatt A Abstract Metabolic reprogramming of tumor cells involves upregulation of fatty acid (FA) synthesis to support high bioenergetic demands and membrane synthesis. This has been shown for cytosolic synthesis of FAs with up to 16 carbon atoms. Synthesis of long-chain fatty acids (LCFAs), including ω-6 and ω-3 polyunsaturated FAs, takes place at the endoplasmic reticulum. Despite increasing evidence for an important role of LCFAs in cancer, the impact of their synthesis in cancer cell growth has scarcely been studied. Here, we demonstrated that silencing of 17β-hydroxysteroid dehydrogenase type 12 (17β-HSD12), essentially catalyzing the 3-ketoacyl-CoA reduction step in LCFA production, modulates proliferation and migration of breast cancer cells in a cell line-dependent manner. Increased proliferation and migration after 17β-HSD12 knockdown were partly mediated by metabolism of arachidonic acid towards COX2 and CYP1B1-derived eicosanoids. Decreased proliferation was rescued by increased glucose concentration and was preceded by reduced ATP production through oxidative phosphorylation and spare respiratory capacity. In addition, 17β-HSD12 silencing was accompanied...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research

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Publication date: Available online 13 November 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Claire Fleurier, Adeline De Wit, Joseph Pilloy, Laura Boivin, Marie-Lise Jourdan, Flavie Arbion, Gilles Body, Lobna OuldamerAbstractPurposeIn the present study, we present a large institutional study to determine the influence of age≥ 80 years on breast cancer presentation and prognosis.MethodsThe study is a retrospective analysis of our prospectively maintained breast cancer database study using data from of women managed from January 2007 through December 2013. Clinicopathologic ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
In this study, we found that Derlin-1 overexpression was higher in breast cancer compared to normal samples through TCGA and GTEx database analyses. Kaplan-Meier plotter analysis showed that Derlin-1 was a predicting factor for patient prognosis. Derlin-1 expression was significantly up-regulated in breast cancer tissues (18/30, 60.00%) compared to corresponding paracancerous tissue (9/30, 30.00%, p 
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
A new study confirms that a CDK4/6 blocker plus endocrine therapy is better than chemotherapy in young women with HR+, HER2- metastatic disease.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Should women with a family history of breast cancer start mammography screening...Read more on AuntMinnie.comRelated Reading: Breast cancer survivors fail to pursue surveillance German study confirms breast screening's mortality reduction Do payouts influence mammography guidelines? Breast cancer screening compliance changes as women age Women born outside U.S. less likely to undergo mammography
Source: Headlines - Category: Radiology Source Type: news
In conclusion, the sugar formulations of PGB-0 only improved PGB-0 solubility but had no role in its cellular uptake.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Conditions:   Metastatic Breast Cancer;   Mutation, Point Intervention:   Sponsor:   Universidad de Costa Rica Recruiting
Source: - Category: Research Source Type: clinical trials
Breast cancer mortality in Germany dropped by more than 20% after the country...Read more on AuntMinnie.comRelated Reading: Do payouts influence mammography guidelines? Breast cancer screening compliance changes as women age Women born outside U.S. less likely to undergo mammography MBI useful in particular breast screening scenarios Synthesized 2D mammography identifies smaller lesions
Source: Headlines - Category: Radiology Source Type: news
This study tried to prepare AgNPs from AgNO3 solution as Ag precursor and Fumaria parviflora (Fp) extract as stabilizing and reducing agents. The anticancer activity of the final product has been studied using human breast cancer cells. Characterization of final products were carried out using UV–visible spectrum, dynamic light scattering (DLS), zeta potential, Fourier transform infrared Spectroscopy (FTIR), X-Ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) techniques. As a result, well-dispersed spherical AgNPs (with the size of lower than ~40 n...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Herbal treatments such as turmeric or ginseng can stop blood from clotting as well as it should and worsen scarring, according to researchers from Nova Medical School in Portugal.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
THURSDAY, Nov. 14, 2019 -- Women with advanced breast cancer might find mindfulness can ease their pain, anxiety and depression, a new study suggests. Mindfulness is the ability to keep your mind focused on the present moment. " Mindfulness helps us...
Source: - Daily MedNews - Category: General Medicine Source Type: news
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