Ultrasound power Doppler and gray scale joint inflammation: What they reveal in rheumatoid arthritis

ConclusionUltrasound PD joint inflammation is associated with disease activity and is correlated with DAS28. In contrast, GS joint inflammation is associated with structural damage and is correlated with ultrasound ‐detected bone erosion.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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In conclusion, osteoporosis is prevalent among RA patients, as a part of a complex transformation of body mass composition, involving BMI and fat mass. The novel QUS scanning technique was able to replicate the results of the established DXA measurement of BMD and is potentially suitable for screening wide populations for osteoporosis. PMID: 31410123 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Conclusions The US demonstrated to be useful to help accurately classify as RA patients previously diagnosed with UA.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
Diagnosing rheumatoid (RA) arthritis often involves subjective assessment of patient hands, X-rays, blood tests, and ultrasound imaging. Researchers at Birmingham University in the UK have now developed a system that they hope will offer a more objec...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Source Type: blogs
ConclusionsUltrasound GS and PD joint inflammation scores can be useful in identifying RA patients with high bone erosion burden (ultrasound erosion score  >  4.5) and high disease activity (DAS28 >  5.1), respectively.
Source: La Radiologia Medica - Category: Radiology Source Type: research
In this study, we analyzed the metabolic profiling of fecal samples from SLE patients and healthy controls based on ultra-high-performance liquid chromatography equipped with mass spectrometry for exploring the potential biomarkers of SLE. The results showed that 23 differential metabolites and 5 perturbed pathways were identified between the two groups, including aminoacyl-tRNA biosynthesis, thiamine metabolism, nitrogen metabolism, tryptophan metabolism, and cyanoamino acid metabolism. In addition, logistic regression and ROC analysis were used to establish a diagnostic model for distinguishing SLE patients from healthy ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Gerard McMahon1,2*, Christopher I. Morse2, Keith Winwood2, Adrian Burden2 and Gladys L. Onambélé2 1Sport and Exercise Sciences Research Institute, Ulster University, Belfast, United Kingdom 2Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Crewe, United Kingdom Introduction: Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that has been shown to modulate muscle mass, and is responsive to exercise training. The effects of resistance training (RT) followed by a short period of detraining on muscle size, architecture and function i...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Rationale: Rheumatoid arthritis (RA) shows a variable clinical expression in patients. Articular disease is common manifestation, but patients may rarely present with extra-articular manifestation such as cranial neuropathy. Also, primary hepatic lymphoma (PHL) has rarely been reported in patient treated with immunosuppressive drug such as methotrexate (MTX) for RA. We herein describe a case of cranial neuropathy and MTX-related PHL in a woman receiving MTX for RA. Patient concerns: A 73-year-old women received MTX treatment for more than 5 years, presented with recurrent cranial neuropathies. During therapy of crania...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
ConclusionA sciatic hernia in women may be manually reduced without surgery. Further reviews of this rare entity are needed to determine the best management strategy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
AbstractOver the last decades, ultrasound (US) has undergone a dramatic evolution in the field of inflammatory joint diseases. Rheumatoid arthritis (RA) is probably the pathology that has most benefited from this development, both in terms of early diagnosis and monitoring of disease activity. The RA-induced morpho-structural changes can be effectively detected and measured by US, and US findings represent an additional advantage over clinical and laboratory evaluation, showing the face of the disease (i.e., proliferative synovitis) and revealing its aggressive behavior (i.e., presence of bone erosions not detectable by co...
Source: La Radiologia Medica - Category: Radiology Source Type: research
An analysis of treat-to-target therapy assessing two ultrasound definitions of remission for patients with early rheumatoid arthritis (RA) has concluded that using ultrasound remission as a target was not associated with better long-term outcomes for RA patients.1 Compared with MRI, ultrasound costs less, is more accessible and offers the ability to scan more joints in... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Research Reviews Rheumatoid Arthritis Remission Criteria Ultrasound Source Type: research
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