An exceptional case of giant cell interstitial pneumonia with multi-organ involvement and review of the literature

Publication date: Available online 15 July 2019Source: Respiratory Medicine Case ReportsAuthor(s): Yanqiu Wei, Peng Chen, Huihui Yue, Gaohong Sheng, Jiaojiao Chu, Hui-Lan ZhangAbstractGiant cell interstitial pneumonia (GIP) is an exceedingly rare lung disease, usually due to occupational exposure to hard-metal compounds (tungsten, carbide, cobalt). Diagnosis of GIP is mainly based on the presence of multinucleated giant cell (MNGC) in alveolar spaces by histologic examination. Here, we present a case of GIP with multi-organ involvement. A 63-year-old man was diagnosed with tuberculosis firstly, but conventional treatment did not relieve the symptoms. In addition, the patient had a contact history with copper for more than 40 years, and the lesions in this patient invaded into lymph node of hilus pulmonis and spread from the primary lung lesion through the blood stream to other organs. And in previous reported cases, the lesions were restricted to the lungs. Finally, numerous prominent multi-nucleated giant cells were noticed by histological examination, the patient eventually diagnosed with GIP. We believe this special case of GIP would provide new perspectives and knowledge of GIP because of the multiorgan involvement.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research

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Children of mothers who contract a bacterial infection such as pneumonia during pregnancy are significantly more likely to have a psychotic disorder in adulthood compared with those not exposed to infection in utero, according to areport inAJP in Advance.The risk of psychosis in adulthood is even greater when pregnant women have an infection that impacts multiple body systems such as sepsis and is especially high for males.Lead author Younga H. Lee, Ph.D., of Brown University and colleagues said more research with larger sample sizes could help uncover how gestational bacterial infection may directly or indirectly cause ad...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance bacterial infection Collaborative Perinatal Project New England Family Study pneumonia psychosis sepsis viral infection Younga Lee Source Type: research
We aimed to assess the main causes of intensive care unit (ICU) readmissions in lung transplant adults and to identify independent predictors of ICU mortality (primary end-point). This Spanish five-centre prospective cohort study enrolled all lung transplant adults with ICU readmissions after post-transplant ICU discharge between 2012 and 2016. Patients were followed until hospital discharge or death. 153 lung transplant recipients presented 174 ICU readmissions at a median (interquartile range) of 6 (2–25) months post-transplant. Chronic lung allograft dysfunction was reported in 39 (25.5%) recipients, 13 of whom (a...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease, Respiratory infections and tuberculosis Original Articles: Infection and lung transplantation Source Type: research
Publication date: Available online 27 September 2019Source: Respiratory Medicine Case ReportsAuthor(s): Daniel Maranatha, Nur Nubli Julian ParadeAbstractEosinophilic chronic obstructive pulmonary disease (COPD) is a COPD phenotype with several clinical characteristics such as eosinophilic airway inflammation, more common in men and less severe COPD. Eosinophilic COPD has more exacerbations but responds well to corticosteroids and bronchodilators. We hereby report the case of a patient who came to us with shortness of breath, fever, wheezing and a cough with yellow phlegm. He had a history of smoking 4.5 pack-year and two e...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Conditions:   Tuberculosis, Pulmonary;   Non-Tuberculous Mycobacterial Pneumonia;   Lung Cancer;   Hemoptysis Intervention:   Sponsor:   Gachon University Gil Medical Center Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 29 August 2019Source: Respiratory Medicine Case ReportsAuthor(s): Petros Oikonomidis, Fotios Fousekis, Panagiotis Kotsaftis, Ioannis Pilios, Dionysios Dimas, Georgios GiannoulisAbstractPulmonary actinomycosis is a rare infectious disease, which is characterized by a wide range of symptoms and no specific imaging findings and may be confused with neoplasia, tuberculosis or pneumonia. Endobronchial involvement of actinomycosis may be caused by aspiration of foreign bodies or broncholithiasis and may bronchoscopically masquerade as malignancy. A case of 68-year-old man is reported, who prese...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Authors: Wang Y, Wang Z, Ding Y, Sun F, Ding X Abstract Background: To investigate the clinical value of HE4 detection in the diagnosis of lung cancer and the clinical significance of combined detection with CEA, NSE and CYFRA21-1. Methods: 90 cases of lung cancer, 30 cases of pulmonary tuberculosis, 30 cases of pneumonia and 30 cases of health physical examination were selected. The levels of serum HE4, CYFRA21-1, CEA and NSE were detected by electrochemiluminescence method. Statistical analysis was performed to observe the sensitivity and specificity. Results: The levels of serum HE4, CEA, NSE and CYFRA21-1 in lu...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
CONCLUSIONS: Patients with a history of lung disease including chronic bronchitis, emphysema, tuberculosis, lung cancer and pneumonia, and a history of thoracic surgery, might have an increased post-acupuncture risk of pneumothorax. This information may possibly help physicians avoid post-acupuncture pneumothorax. PMID: 31433202 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
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