MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1 α

ConclusionsIn conclusion, our study demonstrated that miR-138-5p could promote cardiac ischemia injury via inhibition of the silent information regulator 1 and peroxisome proliferator-initiated receptor gamma and coactivator 1 alpha (SIRT1 –PGC-1α) axis.

http://link.springer.com/10.1007/s00011-019-01268-2

Source: Inflammation Research - July 15, 2019 Category: Research Source Type: research