Erythema Multiforme: Recognition and Management.

Erythema Multiforme: Recognition and Management. Am Fam Physician. 2019 Jul 15;100(2):82-88 Authors: Trayes KP, Love G, Studdiford JS Abstract Erythema multiforme is an immune-mediated reaction that involves the skin and sometimes the mucosa. Classically described as target-like, the erythema multiforme lesions can be isolated, recurrent, or persistent. Most commonly, the lesions of erythema multiforme present symmetrically on the extremities (especially on extensor surfaces) and spread centripetally. Infections, especially herpes simplex virus and Mycoplasma pneumoniae, and medications constitute most of the causes of erythema multiforme; immunizations and autoimmune diseases have also been linked to erythema multiforme. Erythema multiforme can be differentiated from urticaria by the duration of individual lesions. Erythema multiforme lesions are typically fixed for a minimum of seven days, whereas individual urticarial lesions often resolve within one day. Erythema multiforme can be confused with the more serious condition, Stevens-Johnson syndrome; however, Stevens-Johnson syndrome usually contains widespread erythematous or purpuric macules with blisters. The management of erythema multiforme involves symptomatic treatment with topical steroids or antihistamines and treating the underlying etiology, if known. Recurrent erythema multiforme associated with the herpes simplex virus should be treated with prophylactic antiviral therapy. Severe mucosal er...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research

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Publication date: 2019Source: Advances in Virus Research, Volume 104Author(s): Melina Vallbracht, Marija Backovic, Barbara G. Klupp, Felix A. Rey, Thomas C. MettenleiterAbstractMembrane fusion is a fundamental biological process that allows different cellular compartments delimited by a lipid membrane to release or exchange their respective contents. Similarly, enveloped viruses such as alphaherpesviruses exploit membrane fusion to enter and infect their host cells. For infectious entry the prototypic human Herpes simplex viruses 1 and 2 (HSV-1 and -2, collectively termed HSVs) and the porcine Pseudorabies virus (PrV) util...
Source: Advances in Virus Research - Category: Virology Source Type: research
DiscussionWe suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease that develop terminal pulmonary consequences and require a lung transplant.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Goutte J, Killian M, Antoine JC, Massoubre C, Fakra E, Cathébras P Abstract A huge variety of medical diseases may potentially present with isolated psychotic symptoms, and disease-specific treatment or management is available for a significant part of them. The initial medical work-up of a first-episode psychosis (FEP) is of crucial importance. This literature review aimed to identify medical conditions potentially revealed by FEP, to list the warning signs of secondary psychosis, and to discuss a screening strategy. Underlying organic conditions may be drugs and medications, neurologic diseases, i...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
FINDINGSA UCLA study revealed that a gene on the X chromosome may help explain why more women than men develop multiple sclerosis and other autoimmune diseases. Researchers found that a gene known as  Kdm6a was expressed more in women’s immune cells than in men’s, and expressed more in female mice than in males.When the Kdm6a gene was eliminated in mice that were bred to mimic a disease like MS, they had improved symptoms, reduced inflammation and less damage to their spinal cords.BACKGROUNDWomen ’s risk of developing MS is about three times greater than men’s, and women have stronger immu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Conclusions[99mTc]Fucoidan SPECT/CT accurately diagnosed the autoimmune attack in the early steps of EAM and could be used to monitor disease evolution and therapy efficiency.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Autoimmune bullous dermatoses encompass a variety of organ-specific autoimmune diseases that manifest with cutaneous and/or mucosal blisters and erosions. They are characterized by autoantibodies targeting structural proteins of the skin, which are responsible for the intercellular contact between epidermal keratinocytes and for adhesion of the basal keratinocytes to the dermis. The autoantibodies disrupt the adhesive functions, leading to splitting and blister formation. In pemphigus diseases, blisters form intraepidermally, whereas in all other disease types they occur subepidermally. Early identification of autoimmune b...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Foxp3 expressing regulatory T (Treg) cells, as the central negative regulator of adaptive immune system, are essential to suppress immune response and maintain immune homeostasis. However, the function of Treg cells is frequently compromised in autoimmunity and hyper-activated in infections and tumor microenvironments. Thus, manipulating Treg cells becomes a promising therapeutic strategy for treating various diseases. Here we reported that inhibition of Cdk8/Cdk19 activity by small molecule inhibitors CCT251921 or Senexin A greatly promoted the differentiation of Treg cells and the expression of Treg signature genes, such...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self- propagate has a myriad of consequences and yet their biological significance is not well understood. Indeed, retrotransposons have evaded evolutionary attempts at repression and may contribute to somatic mosaicism. Retrotransposons are emerging as potent regulatory elements within the human genome. In the diseased state, there is mounting evidence that endogenous retroelements play a role in etiopathogenesis of inflammatory diseases, with a disposition for bo...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Multiple sclerosis (MS) is a chronic inflammatory, likely autoimmune disease of the central nervous system with a combination of genetic and environmental risk factors, among which Epstein-Barr virus (EBV) infection is a strong suspect. We have previously identified increased autoantibody levels toward the chloride-channel protein Anoctamin 2 (ANO2) in MS....
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Conditions:   Atopic Dermatitis With a History of Eczema Herpeticum;   Atopic Dermatitis Without a History of Eczema Herpeticum;   Health Controls Without Atopy Intervention:   Biological: Xolair Sponsors:   National Jewish Health;   Genentech, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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