Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to...
Source: World Journal of Emergency Surgery - Category: Emergency Medicine Authors: Tags: Research article Source Type: research

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Condition:   Spontaneous Bacterial Peritonitis Interventions:   Drug: Norfloxacin;   Drug: Itopride Sponsor:   Tanta University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionAlthough Meckel’s diverticulitis is a rare entity, it can appear as an acute abdomen. An early diagnosis and treatment to prevent subsequent complications is essential to ensure an optimal recovery.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Condition:   Spontaneous Bacterial Peritonitis Interventions:   Drug: Norfloxacin;   Drug: Itopride Sponsor:   Tanta University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 11 November 2019Source: The American Journal of SurgeryAuthor(s): Federico Coccolini, Daniele Perrina, Marco Ceresoli, Yoram Kluger, Andrew Kirkpatrick, Massimo Sartelli, Luca Ansaloni, Fausto CatenaAbstractIntroductionNo definitive data exist regarding epidemiology and outcomes of patients treated with open abdomen (OA) linked to age.MethodsThis is a prospective, observational, cohort study that includes patients treated with OA. Patients were divided into 4 age groups: group 1: 16–40 y.o.; group 2: 41–60 y.o.; group 3:61–80 y.o.; group 4:> 80 y.o.Results760 patients...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionLPL is related to a higher reoperation rate, more frequent postoperative ongoing sepsis, and higher recurrence rates. Therefore, laparoscopic lavage for perforated diverticulitis carries a high risk of failure in daily practice.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Condition:   Spontaneous Bacterial Peritonitis Interventions:   Drug: Rifaximin;   Drug: Norfloxacin Sponsor:   Ospedali Riuniti di Foggia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we have reported for the first time that VA has an inhibitory role in inflammasome activation. We examined the effect of VA on inflammasome activation and investigated the underlying physiological mechanisms. We verified that VA suppresses IL-1β and caspase-1 secretion, induced by NLRP3 inflammasome activation, in lipopolysaccharide (LPS)-primed bone marrow-derived macrophages. ASC speck formation and oligomerization were also attenuated by VA treatment. VA potentially inhibits NLRP3 inflammasome activation via NLRP3 alkylation. The in vivo efficacy of VA on NLRP3 inflammasome activation was examined in...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 8 November 2019Source: Journal of Visceral SurgeryAuthor(s): M.A. Joly, A. Aime, J.-B. Souraud, B. MalgrasSummaryMyxoglobulosis is a particular, rare, form of appendicular mucocele, characterized by the presence of numerous, occasionally calcified, globules that are grouped together like grapes, and look like pearls or fish eggs, in the appendicular lumen. The diagnosis of myxoglobulosis is most often fortuitous, but sometimes, can be made in the face of acute appendicitis or another setting of abdominal pain. Imaging (sonography or computerized tomography (CT)) is highly suggestive when ...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
CONCLUSIONS: Misdiagnosis frequency is still significantly high and diagnostic delay is long even in a cohort of patients registered after year 2000 in Turkey. Atypical presentation with solo joint attacks, especially among patients with early onset, seems to play a significant role in misdiagnosis and delay in diagnosis. PMID: 31694753 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Sepsis is a complex syndrome resulting from a dysregulated immune response to an infection. Due to the high prevalence, morbidity, and mortality, there is a lot of interest in understanding pathways that play a role in sepsis, with a focus on the immune system. Tumor necrosis factor (TNF) is a pleiotropic pro-inflammatory cytokine and a master regulator of the immune system but clinical trials with TNF blockers in sepsis have failed to demonstrate significant protection. Since TNF stimulates two different receptors, TNF receptor 1 (TNFR1) and TNFR2, pan-TNF inhibition might be suboptimal since both receptors have opposite ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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