Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease.

Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease. Methods Mol Biol. 2019;1948:271-286 Authors: Karikari AA, Koprich JB, Ip CW Abstract The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson's disease has become increasingly accepted to study associated pathology and to use as a platform for therapeutic efficacy testing. We here describe methods to generate such models and how to analyze them by behavioral assessments, histological investigations, and examination of nigrostriatal dopaminergic function. PMID: 30771185 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research