Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease.

Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease. Methods Mol Biol. 2019;1948:271-286 Authors: Karikari AA, Koprich JB, Ip CW Abstract The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson's disease has become increasingly accepted to study associated pathology and to use as a platform for therapeutic efficacy testing. We here describe methods to generate such models and how to analyze them by behavioral assessments, histological investigations, and examination of nigrostriatal dopaminergic function. PMID: 30771185 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research

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Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Conditions:   Parkinson Disease;   Oculomotor; Disorder Interventions:   Other: Control Group;   Other: Oculomotor Training Group Sponsors:   The Hong Kong Polytechnic University;   University of California, Berkeley;   University of Melbourne Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
Conditions:   Follow up;   Parkinson Disease;   Rehabilitation Interventions:   Other: Exercise+FU;   Other: Active Comparator group Exercise Sponsor:   Somogy Megyei Kaposi Mór Teaching Hospital Active, not recruiting
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