Synthesis of Fluorescent Membrane-Spanning Lipids for Studies of Lipid Transfer and Membrane Fusion.

Synthesis of Fluorescent Membrane-Spanning Lipids for Studies of Lipid Transfer and Membrane Fusion. Methods Mol Biol. 2019;1949:307-324 Authors: Schwarzmann G Abstract For uncompromised in vitro assays for intermembrane lipid transfer and membrane fusion fluorescent membrane-spanning lipids have proved to be invaluable tools. These lipids in contrast to phosphoglycerolipids and sphingolipids are resistant to spontaneous as well as protein-mediated intermembrane transfer. Here I describe the synthesis of some homo-substituted fluorescent bipolar membrane-spanning lipids that bear a fluorescent tag either directly or via a phosphoethanolamine spacer to the lipid core. For the synthesis the lipid core of the bipolar membrane-spanning lipids, i.e., the tetraether lipid caldarchaeol, is prepared from cultures of the archaea Thermoplasma acidophilum. PMID: 30790264 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research

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Publication date: Available online 13 September 2019Source: Journal of Alloys and CompoundsAuthor(s): Karuna Kumari, Ashutosh Kumar, Dinesh K. Kotnees, Jayakumar Balakrishnan, Ajay D. Thakur, S.J. RayAbstractNanocomposite made of La0.7Sr0.3MnO3 (LSMO) and reduced graphene oxide (rGO) is a promising candidate for non-volatile memory application in oxide electronics. Here, we report bipolar resistive switching (RS) behaviour in (1-x)LSMO.(x)rGO nanocomposite system, for 0.001 ≤x≤ 0.01. The structural characterisation revealed the presence of individual constituent phases. The switching behaviour is observed to be very ...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
ConclusionsThere is an asymmetry between the increase in the use of antipsychotics in BD and the lack of data regarding the SRA. Phenomenologically, SRA in BD is similar to that found in schizophrenic subjects. Some of these symptoms may be misdiagnosed as depressive symptoms. The existing data show that SRA has a strong correlation with treatment compliance as well as a promising way to develop theoretical paradigms for these disorders.
Source: European Psychiatry - Category: Psychiatry Source Type: research
ConclusionAnimal models that disrupt ion regulation are more inclined to model both mania and depression; and are thus the most promising models available. However, other models are important for demonstrating mechanisms in important pathophysiologic aspect of bipolar disorder.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
In this study, we compared results of bipolar TURP using the resection loop versus vaporization button for treatment of benign prostatic hyperplasia (BPH) to determine the relative safety profile.Patients and methodsBetween January 2013 and March 2014, 89 patients with BPH were randomized to surgical intervention either by Olympus (Gyrus) Bipolar loop TURP or Olympus (Gyrus) Bipolar button vaporization. Inclusion criteria were; BPH with Q-max    18 and prostate volume >  40 g. All patients were evaluated preoperatively and at 1, 3 and 9 months. Evaluation included IPSS, uroflowmetry, pro...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionGhost ileostomy is a simple, safe and feasible technique available in the setting of lower colorectal anastomosis following bowel endometriosis resection.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusion: Despite using a large cohort and highly controlled laboratory conditions, we found no differences in melatonin suppression between euthymic patients with bipolar I disorder and healthy controls. These findings do not support the notion that supersensitivity is a valid endophenotype in bipolar I disorder. PMID: 31509363 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research
We present two cases of schizophrenia, treated with lurasidone developing anemia after variable period of treatment and reverting after stopping lurasidone. These cases emphasize the timely monitoring of blood parameters for prevention or early detection of anemia in patients treated with lurasidone.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
 It seems like every day there is another mass shooting in the news: Newtown, Parkland, Odessa, Dayton. And most of these news reports allude to the shooter having mental illness. But is this true? Common wisdom holds that someone must be mentally ill to do such a thing. But is it really that simple? Join us for a nuanced discussion with Dr. John Grohol, the founder of PsychCentral.com, as he explains how media bias and slanted reporting have contributed to the myths and misunderstandings of who is violent in America. SUBSCRIBE &REVIEW Guest information for ‘Mass Shootings and Mental Illness’ Podca...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Interview Mental Health and Wellness Podcast Psychiatry Psychology The Psych Central Show Violence and Aggression Source Type: blogs
Publication date: Available online 10 September 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Anne J. Bjertrup, Nellie K. Friis, Kamilla W. MiskowiakAbstractMothers’ sensitive responses to their infants have evolutionary importance and are likely hardwired into the maternal brain. Mood disorders are associated with aberrant neural processing of emotion in regions overlapping with ‘maternal sensitivity networks’ and this could compromise maternal processing of infant signals. This systematic review aimed to integrate findings from studies of neural responses to infant stimuli in healthy mot...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
by Beerend H. J. Winkelman, Marcus H. C. Howlett, Maj-Britt H ölzel, Coen Joling, Kathryn H. Fransen, Gobinda Pangeni, Sander Kamermans, Hiraki Sakuta, Masaharu Noda, Huibert J. Simonsz, Maureen A. McCall, Chris I. De Zeeuw, Maarten Kamermans Congenital nystagmus, involuntary oscillating small eye movements, is commonly thought to originate from aberrant interactions between brainstem nuclei and foveal cortical pathways. Here, we investigated whether nystagmus associated with congenital stationary night blindness (CSNB) results from pr imary deficits in the retina. We found that CSNB patients as well as an animal mod...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
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