Guselkumab improves work productivity in patients with moderate-to-severe psoriasis with or without depression and anxiety: results from the VOYAGE 2 comparator study versus adalimumab.

Guselkumab improves work productivity in patients with moderate-to-severe psoriasis with or without depression and anxiety: results from the VOYAGE 2 comparator study versus adalimumab. J Dermatolog Treat. 2019 Jul 15;:1-7 Authors: Reich K, Foley P, Han C, McElligott S, Muser E, Li N, Armstrong AW Abstract Purpose: To evaluate the impact of guselkumab on work productivity, including absenteeism and presenteeism, in psoriasis patients with and without depression/anxiety. Methods: VOYAGE 2 is a randomized, double-blind, placebo-controlled, and comparator-controlled, phase 3 trial that compared guselkumab with adalimumab in patients with moderate-to-severe psoriasis. Absenteeism was evaluated among patients who reported that their skin prevented work/study based on the Dermatology Life Quality Index (DLQI) work/study domain (score = 3) at baseline. Presenteeism was assessed by summarizing mean changes in four Work Limitations Questionnaire (WLQ) domain scores at week 24. Analyses were compared between treatments and stratified by depression/anxiety status at baseline. Results: At week 24, 82.1% and 50.0% in the guselkumab and adalimumab groups, respectively, reported a DLQI work/study score = 0 (no effect of skin on work/study) (p 
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Introduction: Anxiety and depression are comorbidities associated with psoriasis. The total healthcare cost reduction associated with improvements in anxiety and depression in psoriasis patients derived from newer biologic treatments is unknown.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Psoriasis is a chronic, systemic, inflammatory disease involving skin, nails, and joints. Nail psoriasis may lead to many difficulties in daily activities including work and impairment in quality of life and may also be the cause of severe pain, anxiety and depression. A 66-year-old woman with a history of seronegative arthritis receiving methotrexate presented with severe ungual dystrophy affecting all 20 nails. Clinical examination revealed subungual hyperkeratosis, salmon patches, periungual erythema, onycholysis and nail crumbling.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Cai Q, Teeple A, Wu B, Muser E Abstract Objective: To describe the prevalence and costs of anxiety and depression among moderate-to-severe psoriasis (PsO) patients in a commercially-insured US population. Methods: The IBM® MarketScan® Commercial database was used to select adults with moderate-to-severe PsO (≥1 PsO diagnosis and ≥1 systemic or biologic medication) within each calendar year from 2014-2016. Adults with no diagnosis of PsO or similar disorders were randomly selected (2014-2016) and matched 1:1 to PsO patients to compare the prevalence of anxiety and depression each year. Moderat...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
You're reading 5 Surprising Things Stress Can Do to Your Body, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. You just got off a terrible meeting, your boss gave you an impossible deadline for the next project, your team is pushing you to make extra hours, and you still need to pick up the kids at school. Your body is in a “fight or flight response.” Your stress levels are high, you feel your breath get quicker and even feel your heart beating faster than usual. Although this is all a natural response from y...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement stress Source Type: blogs
Authors: Fawaz B, Chamseddin BH, Griffin JR Abstract Mirtazapine has traditionally been used for the treatment of major depressive disorder, with an added benefit in patients who have comorbid insomnia or anxiety. Recent studies describe its usefulness in treating refractory pruritus of various causes as well. Our goal is to better define the use of mirtazapine in the treatment of refractory pruritus. Through a thorough literature review, we identified all reports of the use of mirtazapine for pruritus. We found that mirtazapine has quality evidence for the treatment of intra-thecal morphine-induced pruritus. Mirta...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Conclusions: Children and adults with psoriasis had increased hospitalization for multiple MH disorders, which were associated with a considerable financial burden.Dermatology
Source: Dermatology - Category: Dermatology Source Type: research
Study suggests link between gut bacteria and mental disorders Related items fromOnMedica CCGs expected to stump up more for ailing mental health services Plans for new mental health strategy Psoriasis linked to raised risk of many mental health problems Armed forces wives at greater risk of perinatal depression World ’s first Ministerial Mental Health Summit announced
Source: OnMedica Latest News - Category: UK Health Source Type: news
THURSDAY, May 9, 2019 -- Psoriasis is a chronic, inflammatory skin disease that is often coupled with depression, anxiety and even bipolar disease, schizophrenia and dementia, two new studies show. What is unclear, the researchers acknowledge, is...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSION: Psychiatric and physical disorders carried greatly increased risks and numbers of suicides in South Korea. Schizophrenia was the strongest risk factor, especially 35-65 years, and depression was the most common in suicide victims among ICD-10 disorders in South Korea. PMID: 31042694 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSIONS: Etanercept reduces anxiety and depression in psoriasis patients, and sustained depression correlates with reduced therapeutic response to etanercept. PMID: 31047699 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
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