Cone-beam computed tomography-based delta-radiomics for early response assessment in radiotherapy for locally advanced lung cancer.

Cone-beam computed tomography-based delta-radiomics for early response assessment in radiotherapy for locally advanced lung cancer. Phys Med Biol. 2019 Jul 15;: Authors: Shi L, Rong Y, Daly M, Dyer BA, Benedict S, Qiu J, Yamamoto T Abstract Cone-beam computed tomography (CBCT) images acquired during radiotherapy may allow early response assessment. Previous studies have reported inconsistent findings on an association of CBCT-measured tumor volume changes with clinical outcomes. The purpose of this pilot study was twofold: (1) to characterize changes in CBCT-based radiomics features during treatment; and (2) to quantify the potential association of CBCT-based delta-radiomics features with overall survival in locally advanced lung cancer.
 
 We retrospectively identified 23 patients and calculated 658 radiomics features from each of 11 CBCT images per patient. Feature selection was performed based on repeatability, robustness against contouring uncertainties, and non-redundancy. We calculated the coefficient of determination (R<sup>2</sup>) for the relationship between the actual feature value at the end of treatment and predicted value based on linear models fitted using features between the first and <i>k</i>th fractions. We also quantified the predictive ability for survival with two methods by: (1) comparing delta-radiom...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research