T cells expressing CD26-specific chimeric antigen receptors exhibit extensive self-antigen-driven fratricide.

Conclusion: Eradicating CML-LSCs via anti-CD26-4-1BB-CAR T cells is not applicable, and optimized design or alternative target is needed. PMID: 31303072 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Related Links:

This study included 18 buffy coats collected from volunteer blood donors admitted to the blood transfusion service of IRCCS Bambino Gesù Pediatric Hospital after obtaining informed consent. The Ethical Committee of IRCCS Bambino Gesù Pediatric Hospital approved the study (825/2014) and conducted in accordance with the ethical principles stated in the Declaration of Helsinki. Cells Lines and Cell Culture NK-92 (malignant non-Hodgkin's lymphoma), K562 (chronic myelogenous leukemia, CD19−), Jurkat (acute T cell leukemia, CD19−) Karpas 299 (Human Non-Hodgkin's Ki-positive Large Cell ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Krisztina Banfai1,2, Kitti Garai1,2, David Ernszt2,3, Judit E. Pongracz1,2 and Krisztian Kvell1,2* 1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary 2Szentagothai Research Center, University of Pécs, Pécs, Hungary 3Faculty of Medicine, Institute of Physiology, University of Pécs, Pécs, Hungary During senescence, Wnt4 expression is down-regulated (unlike their Frizzled receptors), while PPARgamma expression increases in the thymus. Together, these changes allow for thymic degeneration to occur, observed as adipose involut...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Acute Bilineal Leukemia;   Minimal Residual Disease;   Myelodysplastic/Myeloproliferative Neoplasm;   Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable;   Myeloproliferative Neoplasm;   Recurrent Acute Biphenotypic Leukemia;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Acute Myeloid Leukemia;   Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm;   Recurrent Chronic Lymphocytic Leukemia;   Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positiv...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsHigh-dimensional imaging of the BM microenvironment by CODEX allows studying the abundance and distribution of cellular elements that are often underestimated or missed by traditional flow cytometry, such as stromal cells, vasculature and megakaryocytes. Importantly, CODEX identifies single cells in their tissue context during leukemic progression and facilitates the discovery of novel cell-cell interactions and cell types as well as unexpected marker constellations.DisclosuresSamusik: Akoya Biosciences: Consultancy, Equity Ownership, Honoraria, Membership on an entity's Board of Directors or advisory committees...
Source: Blood - Category: Hematology Authors: Tags: 631. Chronic Myeloid Leukemia: Biology and Pathophysiology, excluding Therapy: CML Stem Cells And Their Environment Source Type: research
The PD-1/PD-L1 (programmed cell death) pathway is an immune checkpoint, which protects normal tissues but can also prevent anti-tumor immune response. The FDA approvals of checkpoint inhibitors constitutes a major advance in the immunotherapy of cancer [1]. Chronic myeloid leukemia (CML) is an example of successful use of tyrosine kinase inhibitors (TKIs). Blockade of oncogenic BCR-ABL1 kinase activity translated into an impressive control of the disease. CML is also known to be responsive to immunotherapy and long-term eradication of CML has been achieved by allogeneic hematopoietic stem cell transplantation [2].
Source: Leukemia Research - Category: Hematology Authors: Tags: Letter to the Editor Source Type: research
More News: Allergy & Immunology | Cancer | Cancer & Oncology | Chronic Leukemia | Chronic Myeloid Leukaemia | Genetics | Hematology | Immunotherapy | Leukemia | Stem Cell Therapy | Stem Cells