IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors for progressive cell death in these diseases. In particular, the interleukin 1 (IL-1) family consisting of both pro- and anti-inflammatory cytokines has been shown to be pivotal in the mediation of innate immunity and contribute directly to a number of retinal degenerations, including Age-Related Macular Degeneration (AMD), diabetic retinopathy, retinitis pigmentosa, glaucoma and retinopathy of prematurity (ROP). In this review, we will discuss the role of IL-1 family members and inflammasome signalling in retinal degenerative diseases, piecing together their contribution to retinal disease pathology, and identifying areas of research expansion required to further elucidate their function in the retina.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology &Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzheimer&...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
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Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Abstract Retinal degenerative diseases, which include age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and glaucoma, mostly affect the elderly population and are the most common cause of decreased quality of vision or even blindness. So far, there is no satisfactory treatment protocol to prevent, stop, or cure these disorders. A great hope and promise for patients suffering from retinal diseases is represented by stem cell-based therapy that could replace diseased or missing retinal cells and support regeneration. In this respect, mesenchymal stem cells (MSCs) that can be obtained from...
Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
Publication date: 2017 Source:International Review of Neurobiology, Volume 135 Author(s): Abby L. Manthey, Kin Chiu, Kwok-Fai So Lycium barbarum (wolfberry, gogi berry, gouqizi, 枸杞) is one of the most widely used Chinese herbal medicines (CHMs) and is also one of the most scientifically studied. Indeed, the polysaccharide component of this berry (LBP) has been shown to have antioxidant, antiinflammatory, antiexcitotoxic, and antiapoptotic properties. These properties make it a particularly useful treatment option for the ocular environment. Although there are a handful of studies investigating the use of LBP to treat ...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
NEI AGI Seminar in Neuroregenerative Medicine 3-D organoids are the next big thing in disease modeling, drug screening, and tissue sourcing for transplantation. These miniature organs can be grown from patient-derived stem cells, providing a theoretically unlimited supply. David Gamm, M.D., Ph.D., will summarize efforts to develop retinal organoids derived from human pluripotent stem cells. The retina is the light-sensitive tissue in the back of the eye that sends visual signals to the brain. The most common blinding conditions in the U.S. affect the retina, including age-related macular degeneration, diabetic retinopathy,...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Publication date: Available online 27 March 2017 Source:International Review of Neurobiology Author(s): Abby L. Manthey, Kin Chiu, Kwok-Fai So Lycium barbarum (wolfberry, gogi berry, gouqizi, 枸杞) is one of the most widely used Chinese herbal medicines (CHMs) and is also one of the most scientifically studied. Indeed, the polysaccharide component of this berry (LBP) has been shown to have antioxidant, antiinflammatory, antiexcitotoxic, and antiapoptotic properties. These properties make it a particularly useful treatment option for the ocular environment. Although there are a handful of studies investigating the use of...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Abstract Retinal degenerative diseases, which include age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and glaucoma, mostly affect the elderly population, and are the most common cause of decreased quality of vision or even blindness. So far, there is no satisfactory treatment protocol to prevent, stop or cure these disorders. A great hope and promise for patients suffering from retinal diseases is represented by stem cell-based therapy which could replace diseased or missing retinal cells, and support regeneration. In this respect, mesenchymal stem cells (MSCs) which can be obtained fr...
Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
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