Minimizing Earliness/Tardiness costs on multiple machines with an application to surgery scheduling

Publication date: Available online 15 July 2019Source: Operations Research for Health CareAuthor(s): Maarten Otten, Aleida Braaksma, Richard J. BoucherieAbstractEarly or tardy surgeries are frustrating for both patients and personnel, and cause inefficient use of resources at the operating rooms. The stochastic Earliness/Tardiness (E/T) scheduling problem addresses this by minimizing the total expected deviation of the surgery completion times from the planned completion times. We introduce the concept of E/T-concavity as a property of a probability distribution if the E/T costs are concave as a function of the standard deviation of the completion time, whenever the optimal planned completion times are selected. We use this concept to generate an optimal schedule for the multiple machine variant of the E/T problem. The optimal schedule is not unique and therefore allows us to consider several optimization objectives in addition to the E/T objective. We demonstrate the usefulness of our results in practice by proving E/T-concavity for several probability distributions and by showing that, under the assumption of E/T-concavity, a simple Shortest Variance First (SVF) rule is optimal. We conclude by providing a numerical example of surgery scheduling where we demonstrate the benefits of the SVF rule compared to several commonly used scheduling rules.
Source: Operations Research for Health Care - Category: Hospital Management Source Type: research

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In this study, we compared the effects of EFT and PMR in patients with Hwabyung.Design40 patients were enrolled and randomized to receive 4 weeks of group sessions with either EFT (n = 20) or PMR (n = 20). Evaluations were conducted pre- and post-treatment and at 4-week and 24-week follow-ups after session end.Main Outcome MeasuresThe Hwabyung Scale, Visual Analogue Scale of Hwabyung Symptoms (VAS-HS), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and State-Trait Anger Expression Inventory (STAXI) were administered as self-report tools. The analysis excluded 8 patients who never attended tr...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
Publication date: Available online 24 August 2019Source: Revista Española de Cardiología (English Edition)Author(s): Antonio Gippini, Alberto Prado
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 25 August 2019Source: Journal of Cardiology CasesAuthor(s): H.S. Natraj Setty, Nagaraja Moorthy, Jagadeesh Venkatappa, Rangarajan Ramalingam, Shivanand Patil, T.R. Raghu, C.N. ManjunathAbstractA dual left anterior descending (LAD) coronary artery is a rare, and benign congenital anomaly. In this anomaly, there is the presence of two LADs in the anterior inter ventricular sulcus (AIVS). One of the LADs is a short one that ends high in the AIVS. The other longer one enters the distal AIVS and feeds the apex. To date, 9 types of dual LAD variants, and one novel type X has been reported. Here...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Sébastien Marx, Thomas Dal Maso, Jia-Wei Chen, Marina Bury, Johan Wouters, Carine Michiels, Benjamin Le CalvéAbstractThe majority of cancer-associated deaths are related to secondary tumor formation. This multistep process involves the migration of cancer cells to anatomically distant organs. Metastasis formation relies on cancer cell dissemination and survival in the circulatory system, as well as adaptation to the new tissue notably through genetic and/or epigenetic alterations. A large number of proteins are clear...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Ahmad Khurshid, Ju Lee Eun, Shaikh Sibhghatulla, Kumar Anuj, Madhusudana Rao Kummara, Park So-Yong, O Jin Jun, Soo Han Sung, Choi InhoAbstractIntegrins are the main cell surface receptors and execute multifaceted functions such as the bidirectional transmission of signals (i.e., inside-out and outside-in) and provide communication between cells and their microenvironments. Integrins are the key regulators of critical biological functions and contribute significantly to the promotion of cancer at almost every stage of disease progr...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Crescenzo D’Alterio, Stefania Scala, Gabriella Sozzi, Luca Roz, Giulia BertoliniAbstractSeveral lines of compelling pre-clinical evidence identify chemotherapy as a potentially double-edged sword: therapeutic efficacy on the primary tumor may in fact be counterbalanced by the induction of tumor/host reactive responses supportive for survival and dissemination of cancer cell subpopulations. This paradoxical effect of chemotherapy can affect different districts such as the primary tumor, the circulation and distant organs by s...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In conclusion, although human studies are needed, NPs obtained from food-derived flavonoids have promising anticancer effects in vivo.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: September 2019Source: Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 9Author(s):
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: September 2019Source: Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 9Author(s):
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Jun Chen, Shengjun Lu, Xiufang Weng, Zhihui Liang, Xiongwen WuAbstractHLA-A2 is the most common serological HLA type among all ethnic groups. Through advances in DNA typing, more than 800 subtypes of HLA-A2 have been identified, and the existence of heterogeneity of antigen specificity among the HLA-A2 subtypes has been suggested by retrospective analyses of allogeneic transplantation patients and by studies of antigen amino acid structure. However, prior to this study, the antigenicity of a given subtype or the mismatch extent between two giv...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
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