Construction of Doxorubicin-conjugated Lentinan Nanoparticles for Enhancing the Cytotoxocity Effects Against Breast Cancer Cells

Publication date: Available online 14 July 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Ying Wang, Jingwen Chen, Qianqian Han, Qiang Luo, Hongmei Zhang, Yanqing WangAbstractLentinan(LNT) has many kinds of pharmacological activities such as antioxidative activities, hypoglycemic effect, anti-hyperlipidemic effect and so on. Here, LNT was used as the skeleton material to couple with doxorubicin(DOX) by forming the LNT–DOX conjugates in order to enhance anticancer effects and reduce the systemic side effects of DOX. Based on the screening results, we observed that LNT can acted as an antitumor carrier for release of DOX with pH-responsive. DOX release from conjugates was 63.1% at pH 5.0 for up to 48 h, whereas 13.6% of DOX release was observed at pH 7.4 in phosphate buffered saline. The grafting rate of LNT-DOX conjugates was 6.5±0.65 mg/100 mg DOX content. The morphology results showed that LNT-DOX conjugates were considerably more amorphous than LNT. LNT linked by DOX basically maintained the original structure and rheology in water solution. The in vitro anticancer activity of LNT–DOX conjugates was higher than that of free DOX. It is important that LNT–DOX conjugates can enhance anticancer effects in breast cancer cells and decrease the cytotoxocity effects against human normal cells. This work proved that the LNT–DOX conjugates might be suitable for building anticancer drug platform in the course of ch...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research

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