J & J Faces Criminal Probe over Asbestos in Baby Powder

The U.S. Justice Department is conducting a criminal investigation to determine if Johnson &Johnson misled the public about the possible presence of asbestos fibers and the resulting cancer risk in its talcum powder. According to Bloomberg News, a federal grand jury is examining whether company officials knew and denied their product once contained trace amounts of the toxic mineral. An ongoing regulatory investigation and thousands of lawsuits have coincided with the latest probe of the pharmaceutical giant. Johnson &Johnson is the world’s largest manufacturer of talc products, including its iconic Baby Powder. The company announced in February, in its annual report to investors and the Securities and Exchange Commission, that it has been subpoenaed by the Department of Justice as part of an investigation. Its report, though, did not include whether the subpoenas were for criminal or civil matters. Bloomberg broke the news that the probe involved criminal charges and a U.S. grand jury. Department of Justice officials declined comment. Johnson &Johnson Claims Nothing New Johnson &Johnson issued a statement that the company was continuing to cooperate with the Department of Justice investigation. “The key documents on this issue have been publicly available for months on our website. The documents establish that Johnson’s Baby Powder does not contain asbestos or cause cancer,” the statement said. “The implication that there has be...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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ONCOS-102, a promising immunotherapy vaccine, is moving closer to becoming a part of future first-line treatment for mesothelioma. Early clinical trial results announced this week show safety and efficacy when the vaccine is used in combination with standard-of-care chemotherapy for patients with inoperable pleural mesothelioma. Targovax, a Scandinavian pharmaceutical company developing the drug, is moving forward with another study combining ONCOS-102 with a checkpoint inhibitor drug such as Keytruda (pembrolizumab) or Opdivo (nivolumab), along with chemotherapy. “We have seen enough data at this point to be going ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
A team of experts from eight different federal agencies has presented the U.S. Food and Drug Administration with preliminary recommendations to standardize the testing of talc for the presence of asbestos and other potentially harmful mineral products. The recommendations, some of which reject long-held talc industry positions, are designed to end the discrepancies in analysis of whether talc products are contaminated with cancer-causing substances. Preliminary recommendations will be part of the FDA’s public meeting on Feb. 4 to discuss and obtain scientific information on testing for asbestos in talc-based products...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Publication date: Available online 3 January 2020Source: Seminars in Cancer BiologyAuthor(s): Kelly Olino, Tristen Park, Ntia AhujaAbstractAdvances in immunotherapy, most notably antibodies targeting the inhibitory immune receptors cytotoxic T-lymphocyte associated protein 4 (CTLA-4/CD152), programmed death protein 1 (PD-1/CD279) and programmed death-ligand 1 (PD-L1/B7H1/CD274) have become effective standard therapies in advanced malignancies including melanoma,1–4 merkel cell carcinoma5, urological cancers6–8, non-small cell lung cancer9–11, mis-match repair (MMR) deficient tumors12, and Hodgkin lymphoma...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Soltermann Malignant pleural effusion (MPE) is a severe condition of advanced tumors without effective therapy. We used digitalized immunohistochemical and transcriptional approaches to investigate the prognostic influence of immune cells and expression variance of associated immunomodulatory molecules in MPE. Cytology tissue microarrays were constructed from MPE cell blocks of 155 patients with five tumor entities. Immune cells lineage markers were quantified by computational cytopathology on immunohistochemistry. mRNA expression analysis of nine lineage markers and 17 immunomodulators was performed by NanoString. I...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Yuri Noda, Yuko Nakanishi, Kumi Masuda, Masaru YamasakiAbstractSarcomatoid mesothelioma (SM) is the rarest subtype of malignant mesothelioma (MM) with the poorest prognosis. Due to its aggressive nature, early diagnosis and treatment are required for SM, resulting in they significantly improve patient survival. Until now, effusion cytology using ancillary techniques has aided in the early diagnosis of MM, and the cytological findings of the epithelioid component of MM have been well described. However, there has been no detailed cytom...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Abstract Pyridoclax is considered as a promising anticancer drug, acting as a protein-protein interactions disruptor, with potential applications in the treatment of ovarian, lung, and mesothelioma cancers. 18 sensibly selected structural analogs of Pyridoclax were synthesized, and their physico-chemical properties were systematically assessed, and analyzed. Moreover, considering that drug-membrane interactions play an essential role to understand drugs mode of action and eventual toxic effects, membrane models were used to investigate such interactions in the bulk (liposomes) and at the air-water interface. The m...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
A new report reveals Johnson &Johnson rushed the test results of its iconic baby powder to show it was free of asbestos contamination. The Wall Street Journal reported Sunday that two independent laboratories found no evidence of asbestos in the same recalled lot of baby powder used in the U.S Food and Drug Administration report last month. But evidence shows the quick turnaround on the tests may have impacted results. One of those laboratories, commissioned by J&J after the FDA report, initially found asbestos in the talc sample, but quickly recanted. It told J&J the sample had been contaminated by the air-conditio...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Publication date: Available online 14 November 2019Source: European Journal of Surgical OncologyAuthor(s): Aditi Bhatt, Yutaka Yonemura, Sanket Mehta, Nazim Benzerdjeb, Praveen Kammar, Loma Parikh, Mita Y. Shah, Sakina Shaikh BHMS, Aruna Prabhu, Suniti Mishra, Snita Sinukumar, Vahan Kepenekian, Naoual Bakrin, Guillaume Passot, Olivier GlehenAbstractBackgroundThe aim was to study the patterns of target region (greater omentum, lesser omentum, falciform and umbilical round ligament) involvement in patients undergoing cytoreductive surgery (CRS) from various primary tumors, factors affecting involvement and implications on su...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
The Miami Cancer Institute on Thursday will begin using the innovative Tumor Treating Fields device for patients with malignant pleural mesothelioma. It is the first new treatment approved for mesothelioma by the U.S. Food and Drug Administration in more than 15 years. “This is actually pretty exciting for us,” Dr. Rupesh Kotecha, the radiation oncologist who will oversee the treatment protocol in Miami, told The Mesothelioma Center at Asbestos.com. “It’s another tool in our armamentarium. It’s something we can offer patients that has shown a real benefit.” The noninvasive Tumor Treating...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Johnson &Johnson on Friday recalled a single batch of its baby powder as a precaution after government testing found trace amounts of asbestos in one bottle bought online. The recalled lot consists of 33,000 bottles which were distributed last year. J&J said the U.S. Food and Drug Administration found minuscule amounts of asbestos in one bottle during routine testing and notified the company on Thursday. J&J said it immediately began investigating with the FDA. “The FDA’s testing on prior occasions, and as recently as last month, found no asbestos,” said spokesman Ernie Knewitz. J&J said it was checki...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
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