The natural history of pregnancies with prenatal diagnosis of Trisomy 18 or Trisomy 13: Retrospective cases of a 23-year experience in a Brazilian public hospital

This study describes the overall outcome in a country where the therapeutic interruption of pregnancy is not available. The medical records of women with prenatal diagnosis of full trisomy of T13 or T18 between October 1994 and October 2017 were analyzed in order to describe their natural outcomes. Thirteen cases of T13 and 29 cases of T18 were included. The miscarriage rate was 9% for T18 and no cases for T13. Intrauterine fetal death occurred in 46% and 52% of cases for T13 and T18, respectively. The rate of live births for T13 was 54%, and the median survival was one day (95% CI -33.55 - 90.40) and 71% died in the first 24 hours of life. The rate of live births for T18 was 37% and the median survival was two days (95% CI -1.89 - 13.17); 90% of the affected babies died within first week of life. For the affected babies reaching the first year of life and for those who lived longer, multiple invasive and expensive procedures were required, without success in prolonging life beyond 180 days. This large series provides information for professionals and women regarding the natural histories of T13 and T18. Results of this study are consistent with those referenced in the literature, emphasizing the need of structured protocols and guidelines aiming early T13 and T18 diagnosis, prenatal care, gestation/parents follow-up, and counseling processes. For those couples with earlier diagnosis, a better follow-up and counseling during the prenatal care lead to the option for a support ...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research

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This report describes that the prevalences of prepregnancy obesity and gestational diabetes were higher among pregnant women hospitalized for COVID-19-related illness than among those admitted for pregnancy-related treatment or procedures and found to have COVID-19.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Diabetes MMWR Morbidity & Mortality Weekly Report Pregnancy COVID-19 Coronavirus Disease 2019 Source Type: news
This report describes clinical characteristics and birth outcomes of hospitalized U.S. pregnant women with COVID-19 during March 1-August 22, 2020.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Pregnancy Women's Health COVID-19 Coronavirus Disease 2019 Source Type: news
Bryophyte flora of two Natural Parks in Amapá: richness, composition and new records. An Acad Bras Cienc. 2020;92(suppl 2):e20181355 Authors: Oliveira-DA-Silva FR, Ilkiu-Borges AL Abstract The aim of this study is to investigate the richness and composition of the bryophytes of two Municipal Natural Parks in Amapá, eastern Amazon. Bryophytes were collected in the Arivaldo Gomes Barreto Municipal Natural Park (AGBMNP), Macapá municipality, and Cancão Municipal Natural Park (CMNP), Serra do Navio municipality, in October 2010 and October 2012, respectively. Ten plots of 10 x ...
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
In this study, we describe 4 cases of abortion and neonatal deaths from pregnant mares and a she-donkey from different localities in Egypt during the period from May 2015 to October 2017. Attempts were made to isolate and identify EHV-1, in addition to compare the different pathological lesions in various tissues of the necropsied cases. EHV-1 was successfully isolated from two aborted fetuses and one dead neonatal foal from mares, beside one aborted fetus from a she-donkey. The positive cases showed cytopathic effect on embryonated chicken eggs scattered on chorioallantoic membrane. Moreover, PCR was applied for the pock ...
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
Navigating through the many different pre-natal blood tests can be confusing. Names like Sequential Screening, NIPT, and Carrier Screening meant nothing to me before being pregnant. As my doctor explained the different blood tests, I found myself being even more confused. I just wanted to know which blood test was the best option for my baby and me. As you enter your second trimester and prepare to take multiple blood tests, it’s best to do your research beforehand. This way you’ll know what to expect and won’t be overwhelmed by the different options. Here is a breakdown of the different blood tests: Sequ...
Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: pregnancy Source Type: blogs
This study sought to evaluate the causes of this ultrasound sign in a group of patients from Iasi, Romania. During the decade-long study period, there were 71 certified cases involving increased NT; the patients in these cases underwent diagnostic amniocentesis and karyotyping. In most of the examined cases (55 cases, 78%), there was no aneuploidy. The remaining cases involved trisomy 21 (T21) (18%), trisomy 18 (T18) (2%), or triploidy (2%). In most cases, the indication for amniocentesis was increased NT alone (81%), whereas the remaining cases also involved advanced maternal age (5.5%), abnormal serologic markers (10%)...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Sign-up here for a set of week-by-week newsletters so you can follow your baby’s development from now until the beautiful moment of birth. Get Dr. Greene's Pregnancy Newsletter Sign up for Dr. Greene's FREE week-by-week newsletter, timed to your pregnancy to keep you up to date on every stage of your baby's development. Success! Now check your email to confirm your subscription. There was an error submitting your subscription. Please try again. First Name Your baby's due date? ...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Uncategorized Source Type: blogs
Pregnancies complicated by trisomy 13 (T13) or trisomy 18 (T18) present unique challenges for obstetric management. From the initial diagnosis, the task of counseling these women and families is difficult because fetal and neonatal outcomes vary depending on the phenotype and degree of intervention chosen by the family. A literature review was performed using PubMed to gather information regarding obstetric management and outcomes of pregnancies complicated by T13 and T18. Spontaneous abortion and in uterofetal demise occur at rates well above those seen in chromosomally normal pregnancies. In addition, infants with T13 or...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME Articles Source Type: research
Ein Plädoyer für den Ultraschall und für aktuelle Guidelines. Ultraschall Med. 2015 Oct;36(5):424-6 Authors: Tercanli S, Filges I Abstract Without doubt, the importance of ultrasound has increased in many areas in recent years. On the one hand, ultrasound examination as a simple procedure without risk has become an essential part of the clinical routine. Thus, for example, the emergent area of focused ultrasound with a clearly definable target issue is becoming increasingly important for basic diagnosis. On the other hand, highly detailed differential diagnoses can be made in all applic...
Source: Ultraschall in der Medizin - Category: Radiology Authors: Tags: Ultraschall Med Source Type: research
Conclusion This large study has shown that the new cfDNA test is better than current standard screening at detecting three trisomy conditions during pregnancy. The confidence in accurately identifying affected pregnancies was strongest for Down’s syndrome. There were much wider confidence intervals for the other two conditions. The cfDNA test was not 100% accurate, as there were false positive results for each condition, though much fewer than with standard screening. Around 3% of the cfDNA tests did not produce a result. Careful consideration and further research may be needed to decide the best approach in these c...
Source: NHS News Feed - Category: Consumer Health News Tags: Genetics/stem cells Medical practice Pregnancy/child Source Type: news
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