Association of Cystatin C and Bone Mineral Density in Diabetic Patients.

Conditions:   Osteoporosis;   Osteoporosis, Postmenopausal;   Diabetes Mellitus Intervention:   Radiation: Dual-energy X-ray absorptiometry Sponsor:   Fifth Affiliated Hospital, Sun Yat-Sen University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Type 2 diabetes (T2D) is associated with higher bone mineral density (BMD) [1], which is supposed to be associated with lower risk of fracture in the general population. However, individuals with T2D actually have higher risk of fracture, particularly hip fracture [2] and vertebral fracture [3]. Our previous study showed that approximately half of all fractures occurred in those do not have low BMD [4]. This suggested that fractures in patients with diabetes may result from alterations in skeletal properties or bone quality not captured by dual-enery X-ray absorptiometry (DXA)- derived BMD [5].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Conditions:   Osteoporosis;   Osteoporosis, Postmenopausal;   Diabetes Mellitus Intervention:   Radiation: Dual-energy X-ray absorptiometry Sponsor:   Fifth Affiliated Hospital, Sun Yat-Sen University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study included 53 patients with diagnosed primary hyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis of primary hyperparathyroidism and serum levels of CTRP3 measured for all patients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual energy X-ray absorptiometry. Results Serum CTRP3 levels were lower in patients with primary hyperparathyroidism than in the control group (p
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Purpose of review Adrenal tumors occur in 5% of population with higher prevalence in elderly. Patients with adrenal tumors present with overt hormonal excess in up to 15% of cases, and mild autonomous cortisol secretion in 30–40% of cases. Overt Cushing syndrome, mild autonomous cortisol secretion, pheochromocytoma, and primary aldosteronism have been associated with higher cardiovascular morbidity and mortality. Increasing experimental and clinical evidence also suggests that adrenal hormone excess is detrimental to bone health. This review aims to discuss the effect of cortisol, aldosterone, and catecholamine exc...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: ADRENAL CORTEX AND MEDULLA: Edited by Irina Bancos Source Type: research
Conclusions: A significant number of TI patients have high LIC, short stature and endocrine disorders. Patients who require occasional transfusions have more liver iron overload and higher hepatic dysfunction. Females appear to attain better final adult height and have higher IGF1- SDS versus males. Our data emphasize the need for long term surveillance for identification of organ-specific risk factors and early disease manifestations.We also recommend a close monitoring of endocrine and other complications, according to the international guidelines.
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Influence of Habitual Physical Behavior – Sleeping, Sedentarism, Physical Activity – On Bone Health in Community-Dwelling Older People Gladys Onambele-Pearson1*, Jorgen Wullems1,2, Conor Doody1, Declan Ryan1,3, Christopher Morse1 and Hans Degens4,5,6 1Department of Exercise and Sport Science, Manchester Metropolitan University, Manchester, United Kingdom 2Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium 3Faculty of Health and Society, University of Northampton, Northampton, United Kingdom 4School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom 5In...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract BACKGROUND AND PURPOSES: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Recent studies have shown that a single nucleotide polymorphism (SNP) rs6815464 (C/G) in the MAEA gene increases the susceptibility of type 2 diab...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
Conclusions: Low bone mass and deteriorated TBS were noted in approximately two-thirds of T2DM women and was also associated with vertebral fracture. In addition to aging, poor glycemic control may play an important role in bone remodeling, which may be associated with changes in bone strength in T2DM women. Bone strength together with clinical risk factors has the strongest association with fracture, and may potentially be useful to identify women with T2DM at risk.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
ConclusionOur results highlighted that low BMD in patients with CKD is associated with age and hyperparathyroidism, and affects predominantly the hip.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Publication date: Available online 28 November 2018Source: The Lancet Diabetes &EndocrinologyAuthor(s): Elizabeth J Samelson, Kerry E Broe, Hanfei Xu, Laiji Yang, Steven Boyd, Emmanuel Biver, Pawel Szulc, Jonathan Adachi, Shreyasee Amin, Elizabeth Atkinson, Claudie Berger, Lauren Burt, Roland Chapurlat, Thierry Chevalley, Serge Ferrari, David Goltzman, David A Hanley, Marian T Hannan, Sundeep Khosla, Ching-Ti LiuSummaryBackgroundAlthough areal bone mineral density (aBMD) assessed by dual-energy x-ray absorptiometry (DXA) is the clinical standard for determining fracture risk, most older adults who sustain a fracture ha...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
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