Nalbuphine ER Effects of Liver Disease on Pharmacokinetics and Itch

Conditions:   Nalbuphine;   Hepatic Impairment Intervention:   Drug: Nalbuphine ER Sponsors:   Trevi Therapeutics;   Syneos Health Suspended
Source: - Category: Research Source Type: clinical trials

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AbstractPurpose of ReviewPruritus is a common extrahepatic symptom in various liver disorders, in particularly those with cholestatic features. This review summarizes epidemiology, pathophysiology, evidence-based therapeutic recommendations and currently investigated drugs for pruritus in hepatobiliary disorders.Recent FindingsRecent epidemiological data suggest pruritus as a common and relevant symptom in immune-mediated liver diseases, i.e., primary biliary cholangitis (PBC) with over 70% affected patients, up to 56% suffering from chronic pruritus. The better pathophysiological understanding of hepatic pruritus has led ...
Source: Current Gastroenterology Reports - Category: Gastroenterology Source Type: research
Conditions:   Nalbuphine;   Hepatic Impairment Intervention:   Drug: Nalbuphine ER Sponsors:   Trevi Therapeutics;   Syneos Health Suspended
Source: - Category: Research Source Type: clinical trials
New research suggests a connection between nonalcoholic fatty liver disease and a rare pregnancy complication.Medscape Gastroenterology
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news
What began as an annoying itch for Sarka Kralicek turned out to be an incurable liver disease. Now, she hopes to help others recognize the signs of PBC before it's too late.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Nova Scotia Source Type: news
(Digestive Disease Week) A new link has been found between a rare and serious condition that typically presents as itchy palms during pregnancy and the world's most common chronic liver disease, according to research presented at Digestive Disease Week ® (DDW) 2019. Researchers found that intrahepatic cholestasis of pregnancy (ICP), a bile acid disorder in adults that affects roughly one of every 300 pregnancies, may be associated with non-alcoholic fatty liver disease (NAFLD).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusion The elucidation of the function of circRNAs is an emerging field of science with a tremendous potential after previously being dismissed as RNA artifacts. They are ubiquitously expressed and thousands of members have already been identified. This fact only expands their potential to possibly enhance our knowledge to understand the difference between health and disease. Owing to their structure stability and their presence in exosomes circRNAs may also exert their function in an autocrine, paracrine and possible endocrine fashion. In addition, the fact that circRNAs are widely distributed in the cellular compart...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: De Vloo C, Nevens F Abstract Pruritus is a common, troublesome symptom in patients with cholestatic liver diseases, especially frequent in intrahepatic cholestasis of pregnancy (ICP) and in primary biliary cholangitis (PBC). Cholestatic associated pruritus can have profound effects on the quality of life. The underlying mechanism is still poorly understood. Severe potential pruritogens have been discussed, such as bile salts, opioids, steroid and lysophosphatidic acid (LPA), but none of these are considered as key mediators. Because of this unraveling pathophysiology the treatment of hepatogenic pruritus o...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Semin Liver Dis DOI: 10.1055/s-0039-1679918Pruritus is a frustrating and sometimes debilitating symptom that commonly accompanies primary biliary cholangitis (PBC). The mechanism by which this symptom manifests remains elusive but extensive research has now shown that the itch is not just “weak pain” as had been the commonly held belief for decades. As this research now shines a light on the many diverse paths by which pruritus might be experienced, the necessity for a comprehensive approach to the symptom becomes clear. Understanding the interplay between the pathophysiology of PBC and delicately balanced neur...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
Clara Peterson, six, from Green Acres, Washington, was diagnosed when she was an infant with a disease that causes bile salts to build up in liver cells instead of being excreted.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
AbstractChloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever. This acute itching (2 –7 days duration) exhibits age dependency and a racial and genetic predilection. CQ itch is non‐histaminergic, which makes it both a good model and a tool to probe the mechanisms of chronic itch. This review focuses on recently discovered mechanisms, neuroscience, mediators, and receptors that are implicated in molecular studies of CQ pruritus. CQ pruritus mechanisms are also compared to that of itching following other systemic diseases, such as chronic kidney disease, chron...
Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Review Source Type: research
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