Perioperative Atezolizumab With MVA-BN-Brachyury and PROSTVAC For Intermediate-Risk And High-Risk Localized Prostate Cancer

Condition:   Prostate Adenocarcinoma Intervention:   Combination Product: MVA-BN-Brachyury Sponsors:   University of Utah;   Bavarian Nordic;   Genentech, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Condition:   Prostatic Adenocarcinoma Intervention:   Sponsor:   University Hospital, Brest Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed at identifying the cell type/s, if any, expressing PDE5 in human healthy or pathological prostate sections in order to further validate the rationale of PDE5 inhibitor (PDE5i) treatment of benign prostatic hyperplasia (BPH) and their safety in the treatment of erectile dysfunction following prostate cancer (PCa) surgery.Materials and methodsBy immunohistochemical analysis, we studied PDE5 expression in tissue microarrays containing sections obtained from healthy, BPH, and PCa samples.ResultsOur results showed that PDE5 is barely expressed in the epithelial or stromal compartment of normal human prostates, ...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Despite histological evidence in various solid tumor entities, available experience with CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic diseases. With the goal of expanding the application of CXCR4 theranostics to solid tumors, we aimed to elucidate the feasibility of CXCR4-targeted imaging in a variety of such neoplasms. Methods: 19 patients with newly diagnosed, treatment-naïve solid tumors including pancreatic adenocarcinoma or neuroendocrine tumor, cholangiocarcinoma, hepatocellular carcinoma, renal cell carcinoma, ovarian cancer, and prostate cancer underwent [68Ga]Pentixafor PET/...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Biochemically Recurrent Prostate Carcinoma;   Metastatic Prostate Carcinoma;   Prostate Adenocarcinoma;   Prostate Carcinoma;   PSA Level Greater Than Fifty;   PSA Progression;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Pr ostate Cancer AJCC v8 Interventions:   Procedure: Computed Tomography;   Radiation: Gallium Ga 68-labeled PSMA-11;   Procedure...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Prostate Cancer;   Non-metastatic Prostate Cancer;   Prostate Adenocarcinoma Interventions:   Procedure: Radical therapy (radiotherapy or prostatectomy [radiotherapy can be external beam or brachytherapy];   Procedure: Focal therapy;   Procedure: Focal therapy after Finasteride 5Mg tablets for 12 weeks;   Procedure: Focal therapy after Bicalutamide 50Mg tablets for 12 weeks Sponsors:   Imperial College London;   Prostate Cancer UK;   Imperial Clinical Trials Unit (ICTU) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Biochemically Recurrent Prostate Carcinoma;   Metastatic Prostate Carcinoma;   Prostate Adenocarcinoma;   Prostate Carcinoma;   PSA Level Greater Than Fifty;   PSA Progression;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Pr ostate Cancer AJCC v8 Interventions:   Procedure: Computed Tomography;   Radiation: Gallium Ga 68-labeled PSMA-11;   Procedure...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Prostate Cancer;   Non-metastatic Prostate Cancer;   Prostate Adenocarcinoma Interventions:   Procedure: Radical therapy (radiotherapy or prostatectomy [radiotherapy can be external beam or brachytherapy];   Procedure: Focal therapy;   Procedure: Focal therapy after Finasteride 5Mg tablets for 12 weeks;   Procedure: Focal therapy after Bicalutamide 50Mg tablets for 12 weeks Sponsors:   Imperial College London;   Prostate Cancer UK;   Imperial Clinical Trials Unit (ICTU) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Biochemically Recurrent Prostate Carcinoma;   Metastatic Prostate Carcinoma;   Prostate Adenocarcinoma;   Prostate Carcinoma;   PSA Level Greater Than Fifty;   PSA Progression;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Pr ostate Cancer AJCC v8 Interventions:   Procedure: Computed Tomography;   Radiation: Gallium Ga 68-labeled PSMA-11;   Procedure...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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