Role of Rotavirus Vaccination in Decline in Incidence of Type 1 Diabetes —Reply
In Reply We thank Rosenbauer et al and Vajravelu et al for their comments on our Research Letter. Rosenbauer et al requested more details of the statistical methods. We used an interrupted time-series analysis (ITS) on the incidence of newly diagnosed type 1 diabetes (T1D) in children aged 8 years before and after the May 2007 introduction of routine infant oral rotavirus (RV) vaccination. Counts of new T1D cases by age were modeled as Poisson random variables. Publicly available population data for each age group and sex combination in each year were included as an offset in the model, and inference was on the relative change in incidence rates averaged over the preperiod and postperiod.
MONDAY, March 9, 2020 -- Rotavirus vaccination seems not to be associated with type 1 diabetes in children, according to a study published online March 9 in JAMA Pediatrics. Jason M. Glanz, Ph.D., from Kaiser Permanente Colorado in Aurora, and...
This cohort study examines whether there is an association between rotavirus vaccination and incidence of type 1 diabetes among children aged 8 months to 11 years.
This cohort study uses commercial insurance data to examine the association between rotavirus vaccination and type 1 diabetes incidence.
Scientists present a link between rotavirus infection and type 1 diabetes and suggest vaccination as a method to prevent the condition.
To the Editor We read with interest the Research Letter of Perrett et al on the association of rotavirus vaccination with the incidence of type 1 diabetes (T1D) in children in Australia. Comparing the observed or model-based incidence of T1D before and after the introduction of the oral rotavirus vaccination to the Australian National Immunisation Program in 2007, Perrett et al provided evidence that the incidence of T1D in the age group 0 to 4 years has declined by 14% after the introduction of routine rotavirus immunization, while there was observed no change in children aged 5 to 14 years. However, it cannot be excluded...
We reported a decrease in incidence rates of T1D in children aged 0 to 4 years in the period following the introduction of rotavirus vaccination.
To the Editor We read with interest the article by Perrett et al published in JAMA Pediatrics, which used interrupted time-series analysis to study the association of rotavirus (RV) vaccination with incident type 1 diabetes (T1D) in Australia. We believe that given the data presented, the decline in T1D incidence after vaccine introduction is not consistent with the hypothesis that RV vaccine may be protective against T1D development. Rather, the abrupt decrease in incidence around the time of RV vaccine introduction suggests that an alternative cause should be sought.
This article was corrected online.
Children who completed a full course of rotavirus vaccine were at lower risk of developing Type 1 diabetes.
FRIDAY, June 14, 2019 -- Completion of full rotavirus vaccination appears to be associated with a reduction in the risk of type 1 diabetes in children, according to a study published online June 13 in Scientific Reports. Mary A.M. Rogers, Ph.D.,...