NIH begins HIV vaccine trials in North America, South America, Europe

The National Institutes of Health announced plans to begin a phase of trials on Monday on a new HIV vaccine in North and South America, and Europe, which complement an ongoing study with women in Africa.
Source: Health News - - Category: Consumer Health News Source Type: news

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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Rebeca T. Steipel, Matthew D. Gallovic, Cole J. Batty, Eric M. Bachelder, Kristy M. AinslieAbstractAlso known as electrospray, electrohydrodynamic atomization has been used extensively in the last 15 years to develop polymer-based particles for drug delivery in cell and animal models. More recently, novel core-shell, multi-axial, and other electrospray particles have been developed from an array of polymers for a variety of biomedical applications. This review focuses on electrospray as a novel method of particle fabrication...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, 13-15-months-old Holstein-Friesian steers were immunised with a subunit vaccine as a prime and a modified vaccinia Ankara vector as a boost, both expressing a chimeric multi-antigen (rMABbo – rMVA). This antigen includes the immunodominant B and T cell epitopes of three B. bovis proteins: merozoite surface antigen - 2c (MSA - 2c), rhoptry associated protein 1 (RAP - 1) and heat shock protein 20 (HSP20). Responses were compared with the Babesia bovis live attenuated vaccine used in Argentina (R1A). Eleven weeks after the first immunisation, all bovines were challenged by the inoculation of a virulent B....
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we aimed to elucidate the specific amino acids contributing to S2 epitopes. Site mutagenesis and peptide-based enzyme-linked immunosorbent assays (ELISAs) showed that 16R in S2 protein was a key amino acid mediating the antigenicity of S2 protein. S2-derived peptides with 16R, but not those with 16 K, could react with sera against different types of IBVs. Notably, a commercial ELISA kit for detection of antibodies against IBV did not react with sera against all types of IBVs. Taken together, these data demonstrated that S2-derived peptides with 16R could be used as novel marker-based antigens for deve...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Fatemeh Sadat Tabatabaei Mirakabad, Maryam Sadat Khoramgah, Kamyar Keshavarz F., Maryam Tabarzad, Javad RanjbariAbstractPeptides are oligomers of amino acids, which have been used in a wide range of applications, particularly in medical and pharmaceutical sciences. Linear peptides have been extensively developed in various fields of medicine as therapeutics or targeting agents. The branched structure of peptide dendrimers with peptide (commonly, poly l‑Lysine) or non-peptide (commonly poly‑amidoamine) core, often exhibits valuable novel feat...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s): Jessica Hamzelou
Source: New Scientist - Category: Science Source Type: research
Source: Journal of Health Communication - Category: International Medicine & Public Health Authors: Source Type: research
Hey cats, the HypoCat vaccine is being developed for humans. But you are the ones who would get it.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Authors: Tanzella G, Motos A, Battaglini D, Meli A, Torres A Abstract Introduction: Community-acquired pneumonia (CAP) has the highest rate of mortality of all infectious diseases, especially among the elderly. Severe CAP (sCAP) is defined as a CAP in which intensive care management is required and is associated with an unfavorable clinical course. Areas covered: This review aims to identify prevention strategies for reducing the incidence of CAP and optimized management of sCAP. We highlight the main prevention approaches for CAP, focusing on the latest vaccination plans and on the influence of health-risk behavio...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: Available online 16 August 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Paul Baldrick, James W. Hutchings, Matthew D. Heath, Murray A. SkinnerAbstractPQ Birch represents an allergen-specific immunotherapy for the treatment of birch pollinosis. It consists of native birch pollen extract chemically modified with glutaldehyde adsorbed to L-tyrosine in its microcrystalline form with addition of the adjuvant Monophosphoryl Lipid A (MPL®). A nonclinical safety testing strategy was designed based upon interpretation of current legislation and regulatory intelligence and comprised genotoxicity...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
ConclusionsAlthough maternal Tdap and influenza vaccination coverage increased substantially from 2010 to 2017 among large, geographically diverse U.S. cohorts, coverage remained suboptimal, potentially putting newborns at risk of pertussis and influenza. Strategies to increase maternal vaccination coverage could target women identified to have a reduced likelihood of vaccination: those who are younger, black, residing in rural areas, with multiple gestation, and a prepregnancy inpatient admission.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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