Right ventricular dysfunction in neurologically deceased organ donors: An observational study in a tertiary-care organ donor referral centre

ConclusionWe observed a high frequency of RV dysfunction in a sample of potential heart donors. However, the temporal evolution of RV dysfunction, the hemodynamic predictors of RV dysfunction, as well the link between donor RV dysfunction and recipient outcomes need to be assessed with further prospective studies.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research

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The heart transplant (HT) guidelines recommendation to match recipient and donors within 30% of body weight lacks a strong evidence base and is not well established in patients bridged to transplant with left-ventricular-assist-devices (LVAD). In light of scarcity of donor hearts we investigated the effect of size-mismatch on hemodynamics, one-year survival and length of stay (LOS) following HT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
National data demonstrate that increasing opportunities exist for organ donation among hepatitis C virus (HCV) infected individuals.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Lung ischemia/reperfusion (IR) injury contributes to development of severe complications in patients undergoing transplantation. Mesenchymal-stem-cells (MSCs)-derived Extracellular vesicles (EVs) exert beneficial actions comparable to those of MSCs without the risks of the cell-based strategy. The present research investigated EV-effects during IR injury in isolated rat lungs.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Pre-Clinical Science Source Type: research
Background. An impaired cardiac output response to exercise is a hallmark of chronic heart failure (HF). We determined the extent to which impedance cardiography (ICG) during exercise in combination with cardiopulmonary exercise test (CPX) responses reclassified risk for adverse events in patients with HF.Methods and Results. CPX and ICG were performed in 1,236 consecutive patients (48 ±15 years) evaluated for HF. Clinical, ICG and CPX variables were acquired at baseline and subjects were followed for the composite outcome of cardiac-related death, hospitalization for worsening HF, cardiac transplantation, and left ...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
We examined the performance of two commonly used scores in predicting mortality and a composite endpoint (CEP) consisting of ventricular assist device, heart transplantation or mortality, in women versus men with HF.MethodsA retrospective study of 1,136 (25% women) consecutive ambulatory adult HF patients with reduced left ventricular ejection fraction
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract Atherosclerosis is the most common underlying cause of cardiovascular morbidity and mortality worldwide. c-Kit (CD117) is a member of the receptor tyrosine kinase family, which regulates differentiation, proliferation, and survival of multiple cell types. Recent studies have shown that c-Kit and its ligand stem cell factor (SCF) are present in arterial endothelial cells and smooth muscle cells (SMCs). The role of c-Kit in cardiovascular disease remains unclear. The aim of the current study is to determine the role of c-Kit in atherogenesis. For this purpose, atherosclerotic plaques were quantified in c-Ki...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
ConclusionsEarly intensive physical rehabilitation is feasible and safe and may result in improved outcomes and expeditious discharge in VA ECMO patients. Protocol driven multidisciplinary physical therapy with a patient on femorally cannulated VA ‐ECMO retains the advantages of lower extremity peripheral cannulation while eliminating the risks of immobility. The new UNOS allocation system may result in a successful bridge to transplantation in patients on VA‐ECMO due to the increased prioritization of this population to receive donor org ans.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
ConclusionsAtrial fibrillation, but not atrial flutter, was associated with reduced survival in our repaired TOF cohort. Further studies are required to determine if more aggressive antiarrhythmic therapy will improve survival in patients with atrial fibrillation.
Source: American Heart Journal - Category: Cardiology Source Type: research
CONCLUSIONS: Collectively, these differentially expressed proteins represent potential novel diagnostic and therapeutic targets for the treatment of ICM. PMID: 31434864 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
We report a case of TS that worsened with topical cidofovir but improved during an acute cellular rejection episode after the immunosuppression regimen was decreased.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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