Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn's Disease

We aim to provide guidance for medical treatment of luminal Crohn ’s disease in children.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Practice Guideline Source Type: research

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A Case of Bacteriologically Determined De NovoTuberculosis during Tumor Necrosis Factor-α Inhibitor Therapy. Intern Med. 2019 Aug 21;: Authors: Takahashi G, Kobayashi H, Saito Y, Ohsawa S, Suzuki K, Ishihara S, Hisada T Abstract A 58-year-old man with Crohn's disease received adalimumab for 13 months after screening results for tuberculosis were found to be negative. He was diagnosed with de novo mediastinal lymph-node tuberculosis, which was proved to be bacteriologically identical to that of an individual with smear positive lung tuberculosis by a variable number of tandem repeat analyses. Afte...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Case Report Source Type: research
Authors: Kim S, Kang Y, Park S, Koh H, Kim S Abstract BACKGROUND: It has been known that vitamin D level (serum 25[OH]D) has correlation with inflammatory bowel disease (IBD). The purpose of this study is to investigate changes of serum 25[OH]D in pediatric IBD patients according to the disease activity. METHODS: A total of 96 children and adolescent with IBD were enrolled in this retrospective study. Serologic inflammatory markers and clinical disease activity scores of the patients were collected, and their correlations with serum 25[OH]D were analyzed. Seasonal variations of serum 25[OH]D were also investiga...
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Conclusions: Long diagnostic delay in IBD was mainly due to the longer delay in gastroenterologist consultation. Review of the referral system is needed to focus on measures to reduce long delays in diagnosis. The ileal location as a risk factor in CD and age older than 10 years as protective in UC should help recognition and early referral.
Source: The Saudi Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Children with inflammatory bowel disease (IBD) may be at higher risk for psychiatric disorders and suicide attempt, according to a large, population-basedstudy published inJAMA Pediatrics.The risk for psychiatric disorders and suicide among children with IBD was greater when compared with siblings without IBD, indicating that the risk is likely related to IBD itself and not to genetic or environmental factors shared with siblings."Particularly concerning is the increased risk of suicide attempt," wrote Agnieszka Butwicka, M.D., Ph.D., of the Karolinska Institute in Sweden and colleagues. "Long-term psycholog...
Source: Psychiatr News - Category: Psychiatry Tags: ADHD anxiety autism Crohn's disease IBD inflammatory bowel disease mood disorders personality disorders suicide ulcerative colitis Source Type: research
Condition:   Crohn Disease Intervention:   Other: Soy based diet Sponsors:   Case Western Reserve University;   University of California, Davis;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University Hospitals Cleveland Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The Crohn’s-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC. CLR is characterized by peritumoral lymphocytic aggregates that are found at the advancing edge of the tumor. Spatial and molecular characterization of CLR within the tumor microenvironment (TME) have uncovered a spectrum of peritumoral lymphoid aggregates with varying levels of organization and maturation. In early stages of CLR development, CD4+ T-cells cluster predominantly with mature antigen presenting dendritic cells. As CLR matures, inc...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We report a case of a 46-year-old Chinese male who presented with six months history of abdominal pain, weight loss and rectal bleeding. Diagnostic colonoscopy revealed multiple aphthous ulcers within the ileo-caecal region and distal transverse colon, separated by normal mucosa, mimicking skip lesions of Crohn's colitis. Computer topography (CT) scan of the abdomen showed multiple circumferential thickenings involving predominantly the right colon. A clinical diagnosis of colonic Crohn's disease with possible perforation was made. An extended right hemicolectomy was performed due to uncontrolled rectal bleeding. Histopath...
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
Introduction: Inflammatory bowel disease (IBD) and hidradenitis suppurativa (HS) are both chronic inflammatory diseases with a big impact in the quality of life of the patients. It has been described a higher prevalence of HS among patients diagnosed with IBD, especially Crohn disease. Some drugs used in HS, such as antibiotics, can be harmful for IBD patients and they may trigger flare ups. Adalimumab is anti-TNF drug which is approved for the treatment of both diseases, being the doses similar in both disorders.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: The pathogenesis of psoriasis may involve a breakdown of immune tolerance to cutaneous microorganisms. Guttate and chronic plaque psoriasis are associated with Streptococcus pyogenes colonization. In addition, Crohn disease and periodontitis, two diseases due to immune activation in response to microbiota, have been reported at a higher incidence in patients with psoriasis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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