Protective role of endothelial progenitor cells stimulated by riociguat in chronic thromboembolic pulmonary hypertension

Pulmonary endothelial damage has a negative impact on the maintenance of normal pulmonary vascular function. Such damage results in delayed thrombus dissolution and vascular remodeling in chronic thromboembolic pulmonary hypertension (CTEPH). Although endothelial progenitor cells (EPCs) may be incorporated into neovasculature during vascular repair, their function in CTEPH remains unclarified, especially under the augmentation of soluble guanylate cyclase (sGC) activity.

Source: International Journal of Cardiology - July 14, 2019 Category: Cardiology Authors: Keiko Yamamoto, Rintaro Nishimura, Fumiaki Kato, Akira Naito, Rika Suda, Ayumi Sekine, Takayuki Jujo, Ayako Shigeta, Seiichiro Sakao, Nobuhiro Tanabe, Koichiro Tatsumi Source Type: research