Age-adjusted association of homologous recombination genes with ovarian cancer using clinical exomes as controls

ConclusionThe lack of association of PVs inBRIP1 with OC by ORAdj is inconsistent with some previous literature and current management recommendations, highlighted by the significantly older age of OC onset forBRIP1 PV carriers compared to non-carriers. By reporting ORAdj, this study presents associations that reflect more informed genetic contributions to OC when compared to traditional count-based methods.

http://link.springer.com/10.1186/s13053-019-0119-3

Source: Hereditary Cancer in Clinical Practice - July 14, 2019 Category: Cancer & Oncology Source Type: research