Discovery and validation of methylated-differentially expressed genes in Helicobacter pylori-induced gastric cancer

Cancer Gene Therapy, Published online: 16 July 2019; doi:10.1038/s41417-019-0125-7Discovery and validation of methylated-differentially expressed genes in Helicobacter pylori-induced gastric cancer
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research

Related Links:

Gastric cancer remains one of the most common causes of cancer deaths worldwide. The best current option for reducing gastric cancer deaths is Helicobacter pylori eradication combined with risk assessment and surveillance programs for those deemed to be at high risk for gastric cancer so as to identify lesions at a stage amenable to curative therapy. In this issue, Nam et  al1 report a retrospective study of Helicobacter pylori eradication on gastric cancer incidence among 10,328 Korean adults undergoing health checkups including an H pylori test-and-treat program.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Cell Death &Disease, Published online: 19 August 2019; doi:10.1038/s41419-019-1859-8SIRT1-targeted miR-543 autophagy inhibition and epithelial–mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Authors: Song H, Zhou L, Liu D, Ge L, Li Y Abstract Helicobacter pylori (H. pylori) is a major cause of chronic gastritis, gastric ulcers and gastric cancer. Recent studies have identified that probiotics are beneficial to human health due, in part, to their anti-H. pylori activities. Therefore, the present study investigated the antagonistic and local immunoregulatory activities of seven commercial probiotic strains and explored their mechanisms of actions. The human gastric epithelial cell line-1 (GES-1) was used to assess the effects of probiotics on the adhesion ability of H. pylori. GES-1 cells were infected w...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
AbstractDespite being one of the most studied cancer-related infections, the relationship betweenHelicobacter pylori infection and gastric adenocarcinoma (GC) remains, in some points, obscure. Based on a critical analysis of the available literature regarding stomach microbiota, we aimed to shed light to a possible new interpretation of the current understanding about theHelicobacter pylori-related GC carcinogenesis. We analyzed data from the literature onHelicobacter pylori and other potential carcinogenic pathogens, in both benignant conditions and gastric adenocarcinoma.Helicobacter pylori is the dominant microorganism ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Helicobacter pylori (H. pylori) infection in gastric mucosa is the main risk factor for gastric cancer. The purpose of this study was to assess the value of the linked-color imaging (LCI) score for the identification of H. pylori-associated gastritis.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Digestive Endoscopy Source Type: research
Tegtmeyer The gastric pathogen and carcinogen Helicobacter pylori (H. pylori) encodes a type IV secretion system for translocation of the effector protein CagA into host cells. Injected CagA becomes tyrosine-phosphorylated at the five amino acid residue Glutamate-Proline- Isoleucine-Tyrosine-Alanine (EPIYA)-sequence motifs. These phosphorylated EPIYA-sites represent recognition motifs for binding of multiple host factors, which then manipulate signaling pathways to trigger gastric disease. Thus, efficient detection of single phosphorylated EPIYA-motifs in CagA is required. Detection of phospho-CagA is primarily perfo...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractHelicobacter pylori (H. pylori) infection is a common disease that can cause chronic gastritis, peptic ulcers, and gastric cancer. Nevertheless, due to its ability to elicit a systemic inflammatory response, it has also been related to several extra-gastric manifestations including endocrine disorders, such as autoimmune thyroid diseases, diabetes mellitus, dyslipidemia, and obesity.H. pylori infection has also been linked to osteoporosis, although currently available data are equivocal. This brief review will focus on the possible association betweenH. pylori infection and osteoporosis, a silent disease characteri...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Authors: Huang RJ, Choi AY, Truong CD, Yeh MM, Hwang JH Abstract Gastric intestinal metaplasia (GIM) is a known premalignant condition of the human stomach along the pathway to gastric cancer (GC). Histologically, GIM represents the replacement of normal gastric mucosa by mucin-secreting intestinal mucosa. Helicobacter pylori infection is the most common etiologic agent of GIM development worldwide. The prevalence of GIM is heterogeneous among different regions of the world and correlates with the population endemicity of H. pylori carriage, among other environmental factors. GC remains the third leading cause of c...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Diabetes appears to increase the risk of gastric cancer after Helicobacter pylori eradication, especially in patients with suboptimal glycemic control, according to a database study.Reuters Health Information
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
More News: Cancer | Cancer & Oncology | Gastric (Stomach) Cancer | Gastroenterology | Gene Therapy | Genetics | Helicobacter Pylori