Evaluation of < i > Burkholderia mallei < /i > Δ < i > tonB < /i > Δ < i > hcp1 < /i > (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

Conclusions/SignificanceOur data indicate that CLH001 serves as an effective live attenuated vaccine to prevent glanders and melioidosis. The quantity and quality of antibody responses as well as improving cell-mediated immune responses following vaccination need to be further investigated prior to advancement to preclinical studies.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research