Postoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertension.

Postoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertension. Bosn J Basic Med Sci. 2019 Jul 03;: Authors: Kruthiventi SC, Kane GC, Sprung J, Weingarten TN, Warner ME Abstract Patients with pulmonary hypertension are at increased risk for postoperative pulmonary complications (PPCs). Herein, we review PPCs in pulmonary hypertension patients undergoing non-cardiac procedures under general anesthesia. The medical records of pulmonary hypertension patients who underwent surgery with general anesthesia between 2010 and 2017 were reviewed for PPCs. In addition we reviewed nursing-documented respiratory depressive episodes in the post-anesthesia care unit to assess the associations between these episodes and later PPCs. There were 20 PPCs among 128 patients who underwent 197 procedures (10.2 per 100 surgeries) [95% CI 6.7-15.2]. Of these, 5 occurred during anesthesia recovery and 15 following anesthesia recovery. Three-quarters of the PPCs occurred within 24 postoperative hours. All the PPCs were severe. The frequency of PPCs was significantly higher in those who experienced respiratory depression during anesthesia recovery vs. in those who did not (5/17, 29% vs. 10/175, 6%; odds ratio 5.15, 95% CI 1.58-16.81, p = 0.007). Increased PPC rates were observed among patients who were current/previous smokers and who routinely use benzodiazepines, and among those undergoing emergent surgery. With treatment, all PPCs resolved. T...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

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AbstractSystemic sclerosis (SSc) is a chronic, systemic disease characterized by fibrosis of the skin and internal organs, vasculopathy, and auto-immune activation. On the top of severe organ involvement such as interstitial lung and myocardial fibrosis, pulmonary hypertension, and renal crisis, individuals diagnosed with SSc may suffer from a number of comorbidities. This is a narrative review according to published recommendations and we searched the online databases MEDLINE and EMBASE using as key words the following terms: systemic sclerosis, scleroderma, myocardial fibrosis in combination with micro- and macro-vascula...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Algorithms, datasets, machine learning, deep learning, cognitive computing, big data, and artificial intelligence: IT expressions that took over the language of 21st-century healthcare with surprising force. If medical professionals want to get ahead of the curve, they rather get familiarized with the basics of A.I. and have an idea of what medical problems they aim to solve. So, let’s take a closer look at machine learning and deep learning in medicine. The ante-room of artificial intelligence The term “artificial intelligence” might be misleading as due to the overuse of the expression, its meanin...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence in Medicine Future of Medicine AI algorithm deep learning Health Healthcare Innovation machine learning smart smart algorithm smart health technology Source Type: blogs
Publication date: Available online 25 April 2019Source: American Heart JournalAuthor(s): Haider J Warraich, Larry A Allen, Laura J Blue, Erin L Chaussee, Jocelyn S Thompson, Colleen K McIlvennan, Kelsey M Flint, Daniel D Matlock, Chetan B. PatelAbstractBackgroundPatients considering destination therapy left ventricular assist devices (DT LVAD) often have high comorbid burden but the association between these comorbidities and post-decision outcomes is unknown.MethodsWe included subjects in DECIDE-LVAD (NCT02344576), a stepped-wedge multicenter trial of patients considering LVADs, recording comorbidities per INTERMACS proto...
Source: American Heart Journal - Category: Cardiology Source Type: research
This study sought to evaluate the impact of prosthesis-patient mismatch on the risk of perioperative and long-term mortality after mitral valve replacement. Methods: Databases were researched for studies published until December 2018. Main outcomes of interest were perioperative and 10-year mortality and echocardiographic parameters. Results: The research yielded 2,985 studies for inclusion. Of these, 16 articles were analyzed, and their data extracted. The total number of patients included was 10,239, who underwent mitral valve replacement. The incidence of prosthesis-patient mismatch after mitral valve replacement was 53...
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 31 December 2018Source: Life SciencesAuthor(s): Yi-Tao Zhang, Jiao-Jie Xue, Qing Wang, Shi-Yao Cheng, Zhi-Chong Chen, Hua-Yang Li, Jia-Jie Shan, Kang-Lin Cheng, Wei-Jie ZengAbstractAimPulmonary hypertension due to left heart failure (PH-LHF) is the most common cause of pulmonary hypertension. However, therapies for PH-LHF are lacking. Therefore, we investigated the effects and potential mechanism of dehydroepiandrosterone (DHEA) treatment in an experimental model of PH-LHF.Main methodPH-LHF was induced in rats via ascending aortic banding. The rats then received daily DHEA from Day 1 to D...
Source: Life Sciences - Category: Biology Source Type: research
In conclusion, patients presenting for late arterial switch operation are at risk for left ventricular deconditioning and pulmonary hypertension. Deconditioned left ventricle may fail post repair with inability to handle systemic circulation. Among limited options for these challenging cases primary ASO with integrated ECMO support can be used to allow deconditioned left ventricle to recover its function and ability to handle systemic circulation.
Source: The Egyptian Journal of Critical Care Medicine - Category: Intensive Care Source Type: research
Conclusion: Overall, home based primary care seems to be a promising alternative for pts with SCD. It had a significant impact on patient quality of care and may improve prescription adherence, but more data are needed to determine if it has an effect on healthcare utilization for pts with SCD.DisclosuresMoore: Ohio State University College of Medicine: Research Funding. Desai: FDA: Research Funding; Pfizer: Research Funding; University of Pittsburgh: Research Funding; Selexy/Novartis: Research Funding; NIH: Research Funding; Ironwood: Other: Adjudication Committee.
Source: Blood - Category: Hematology Authors: Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research
Physical activity has been reported to be reduced in patients with chronic obstructive pulmonary disease (COPD), which is associated with higher risks of exacerbation and mortality. Physical inactivity in COPD can be affected not only by lung function, but also by extra-pulmonary comorbidities.We conducted a cross-sectional study with a series of tests including lung function, physical activity, and comorbidities. Eighty outpatients with stable COPD were recruited, and relationship between comorbidities and physical activity was evaluated. Physical activity was assessed through 14 consecutive days by a triaxial acceleromet...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: Study showed that 6MWD could be associated with pulmonary function results and especially with the physical parameters of QoL. However, anxiety, depression or mental parameters have no effect on 6MWD among patients with PH. Studies with different factors are needed for further researches.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and Chronic Care Source Type: research
Conclusion: The EmPHasis-10 the Turkish version is a QoL questionnaire with a high level of validity and reliability, which can be used easily by academicians and clinicians conducting research.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
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