Non-enzymatic D-glucose plasmonic optical fiber grating biosensor

Publication date: Available online 14 July 2019Source: Biosensors and BioelectronicsAuthor(s): Maxime Lobry, Driss Lahem, Médéric Loyez, Marc Debliquy, Karima Chah, Mariel David, Christophe CaucheteurAbstractSaccharide sensors represent a broad research area in the scope of sensing devices and their involvement in the medical diagnosis field is particularly relevant for cancer detection at early stage. In that context, we present a non-enzymatic optical fiber-based sensor that makes use of plasmon-assisted tilted fiber Bragg gratings (TFBGs) functionalized for D-glucose biosensing through polydopamine (PDA)-immobilized concanavalin A (Con A). Our probe allows a live and accurate monitoring of the PDA layer deposition leading improved surface biochemistry. The SPR shift observed was assessed to 3.83 ± 0.05 nm within 20 min for a 2 mg/mL dopamine solution. Tests performed in different D-Glucose solutions have revealed a limit of detection close to 10−7 M with the highest sensitivity in the 10−6 to 10−4 M range. This configuration has the capability to overcome the limitations of current enzyme-based solutions.
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research