Lynch Syndrome and Urologic Malignancies Lynch Syndrome and Urologic Malignancies

Get up-to-date on the most recent developments regarding lynch syndrome-associated urologic malignancies.Current Opinion in Urology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Urology Journal Article Source Type: news

Related Links:

Lynch syndrome is the most common inherited cause of colorectal cancer (CRC). Contemporary and mutation-specific estimates of CRC-risk in patients undergoing colonoscopy would optimize surveillance strategies. We performed a prospective national cohort study, using data from New Zealand, to assess overall and mutation-specific risk of CRC in patients with Lynch syndrome undergoing surveillance.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Conclusion: These observations suggest that early onset colorectal cancer and AML may be related diseases.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
DR ROBERT CIMA (Rochester, MN): The authors present a single-institution experience of patients with genetically confirmed Lynch syndrome, who underwent segmental colectomy as treatment for index colon cancer. The natural history of these patients is not well described in the literature, and it suggests it is tied to their underlying genetic profile.
Source: Journal of the American College of Surgeons - Category: Surgery Tags: Southern surgical association article Source Type: research
Lynch syndrome is the most common inherited cause of gastrointestinal cancer. Although current guidelines recommend endoscopic screening for gastric cancer and Helicobacter pylori infection in carriers of germline variants causing Lynch syndrome, there are limited data to support these recommendations.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Issue Highlights Source Type: research
The original version of this article unfortunately contained a mistake. The variants listed in Table 3 of the original version of this article are not in line with the latest HGVS (Human Genome Variation Society) nomenclature (version 19.01).
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
Abstract Patients with hereditary predisposition to digestive cancer are at high risk of neoplasia and management in expert centers is recommended. The PRED-IdF network was thus created in 2009, with the support of the French National Cancer Institute (INCa), covering Paris and its suburbs, including five teaching hospitals and two oncology-dedicated institutes. The aim of this network is to offer optimized cancer screening programs based on expert recommendations to patients with hereditary predisposition. Any patient with suspicion of hereditary colorectal syndrome can be referred to the PRED-IdF network. The mi...
Source: Annales de Pathologie - Category: Pathology Authors: Tags: Ann Pathol Source Type: research
CONCLUSIONS: BRCA1 carriers have the highest risk of occult neoplasia at RRSO, and the frequency increased with age. Women with BRCA1/2 mutations often have RRSO beyond recommended ages. One PALB2 carrier had FT intraepithelial neoplasia, a novel finding. Serial sectioning is critical to identifying occult neoplasia and should be performed for all risk-reducing surgeries. PMID: 32199636 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
Gazič Krajc Novaković The diagnostics of Lynch syndrome (LS) is focused on the detection of DNA mismatch repair (MMR) system deficiency. MMR deficiency can be detected on tumor tissue by microsatellite instability (MSI) using molecular genetic test or by loss of expression of one of the four proteins (MLH1, MSH2, MSH6, and PMS2) involved in the MMR system using immunohistochemistry (IHC) staining. According to the National Comprehensive Cancer Network (NCCN) guidelines, definitive diagnosis of LS requires the identification of the germline pathogenic variant in one of the MMR genes. In the report, we are presen...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Endometrial sampling for the surveillance of women with Lynch syndrome is an invasive and painful procedure. The aim of this study was to evaluate the feasibility of a less invasive procedure of collecting vit...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
AbstractThe aims of the Prospective Lynch Syndrome Database (PLSD) are to provide empirical prospectively observed data on the incidences of cancer in different organs, survival following cancer and the effects of interventions in carriers of pathogenic variants of the mismatch repair genes (path_MMR) categorized by age, gene and gender. Although PLSD is assumption-free, as with any study the ascertainment procedures used to identify the study cohort will introduce selection biases which have to be declared and considered in detail in order to provide robust and valid results. This paper provides a commentary on the method...
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research
More News: Cancer & Oncology | Health | HNPCC | Lynch Syndrome | Urology & Nephrology