Oxaliplatin induces prostaglandin E2 release in vascular endothelial cells

ConclusionsThis study indicates that L-OHP treatment specifically upregulated PGE2 secretion by vascular endothelial cells, which may contribute to vascular pain, and that NSAIDs can be used to inhibit PGE2 release and attenuate L-OHP-induced hyperalgesia.

Source: Cancer Chemotherapy and Pharmacology - July 15, 2019 Category: Cancer & Oncology Source Type: research