Anaplasma ovis in sheep: experimental infection, vertical transmission and colostral immunity

Publication date: Available online 13 July 2019Source: Small Ruminant ResearchAuthor(s): C. Jiménez, A. Benito, J.L. Arnal, A. Ortín, M. Gómez, A. López, S. Villanueva-Saz, D. LacastaAbstractOvine anaplasmosis is caused by the obligate intraerythrocytic bacteria Anaplasma ovis and the disease is characterized by anaemia, weight loss and weakness. A severe outbreak of ovine anaplasmosis was diagnosed for the first time in Spain in 2014 and, subsequently, a research was developed in order to increase de knowledge of this not-well-known disease.An experimental infection with Anaplasma ovis was carried out in three lambs and the evolution of the disease was assessed during a period of three years and two production cycles (gestation, birth and lactation). Clinical and haematological parameters were analyzed through all the period and detection of Anaplasma ovis by qPCR and Giemsa staining of blood smears was performed periodically as well as cELISA test for the detection of antibodies against Anaplasma spp. Finally, Anaplasma ovis vertical transmission and transfer of immunity through the colostrum were studied and evaluation of the immune response against infection of lambs born from infected dams was likewise analyzed by means of a new experimental infection.The results showed that A. ovis induces a severe normocytic and normochromic anaemia, however, evident clinical signs were not observed until the first lambing. Molecular identification of Anapla...
Source: Small Ruminant Research - Category: Zoology Source Type: research

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In conclusion, it is recommended that in addition to direct microscopic examination, the use of additional methods such as culture and PCR will be useful in routine laboratory diagnosis of Blastocystis spp. The distribution of Blastocystis subtype in Aydin is mainly in accordance with the global findings. Lack of a relationship between Blastocystis spp. ─░nfection and symptoms in our study was supported the idea that Blastocystis spp. infection is mostly asymptomatic in humans and it may be a member of healthy microbiota. PMID: 31414632 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
ConclusionThis study supports the cross-language measurement equivalence of BRAF-MDQ and RAID and provides further support for the psychometric properties of these measures in RA.
Source: Quality of Life Research - Category: Health Management Source Type: research
Authors: Foresto RD, Santos DWCL, Hazin MAA, Leyton ATZ, Tenório NC, Viana LA, Cristelli MP, Silva Júnior HT, Pestana JOM Abstract In 2004, a global spread of Chikungunya fever affected most tropical and subtropical regions of the world. In 2016, an outbreak occurred in Northeast Brazil with hundreds of cases documented. Solid organ transplant recipients have a modified immune response to infection and the clinical course is usually different from immunocompetent patients. The diagnosis can be challenging in this population. Most reports describe patients residing in endemic areas, although we must em...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Publication date: Available online 15 August 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Nermeen N. El-Agroudy, Anica Kurzbach, Roman N. Rodionov, John O’Sullivan, Michael Roden, Andreas L. Birkenfeld, Dominik H. PestaNonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies, effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training, are currently the t...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
ConclusionsAs disparities in maternal and infant outcomes were present, nutritional intervention(s) need to be targeted toward prevention of adverse pregnancy outcomes, prioritization of higher-risk groups and adaptation of the program to a multiethnic low-income population.RésuméObjectifLa présente étude a pour objectif principal de caractériser le taux d'issues de grossesse indésirables dans un groupe multiculturel composé de femmes à faible revenu.MéthodesLes données extraites entre juin 2013 et décembre 2015 provenaient de la base de donn&eacu...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
The phase III PROSELICA trial showed that cabazitaxel 20 mg/m2 (C20) was not inferior and better tolerated compared to cabazitaxel 25 mg/m2 (C25) in patients with metastatic castration-resistant prostate cancer (mCRPC) who had progressed during or after docetaxel. Here, we report on a real-world retrospective analysis concerning the safety and the activity of C20 schedule in patients with mCRPC treated at our Institution. We identified 35 patients with mCRPC who received C20 as baseline dose treatment because they were frail or experienced serious toxicities to previous treatments. Adverse events assessment was performed a...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Clinical Papers Source Type: research
GIDEON what’s new summary: August 16 to August 17, 2019 Infectious Diseases – Outbreaks (12 updates) 12 DiseasesMap The post Update: August 17, 2019 appeared first on GIDEON - Global Infectious Diseases and Epidemiology Online Network.
Source: GIDEON blog - Category: Databases & Libraries Authors: Tags: What's New Source Type: blogs
ConclusionsPRES syndrome has an overall good prognosis and the evolution to epilepsy is rare. The severity and duration of PSH or seizure severity and EEG findings at PRES onset are not associated with worse neurological outcomes.
Source: Seizure - Category: Neurology Source Type: research
GIDEON what’s new summary: August 16 to August 16, 2019 Infectious Diseases – Outbreaks (13 updates) 13 DiseasesMap The post Update: August 16, 2019 appeared first on GIDEON - Global Infectious Diseases and Epidemiology Online Network.
Source: GIDEON blog - Category: Databases & Libraries Authors: Tags: What's New Source Type: blogs
DiscussionThe present study will investigate the probable cellular pathways for the anti-obesity effects ofN. sativa in overweight/obese women.Trial registrationIranian Registry of Clinical Trials,IRCT20180528039884N1. Registered on 2nd of July, 2018.
Source: Trials - Category: Research Source Type: clinical trials
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