1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.
Bioorg Med Chem. 2019 Jul 04;:
Authors: Bozorov K, Zhao J, Aisa HA
Abstract
The 1,2,3-triazole ring is a major pharmacophore system among nitrogen-containing heterocycles. These five-membered heterocyclic motifs with three nitrogen heteroatoms can be prepared easily using 'click' chemistry with copper- or ruthenium-catalysed azide-alkyne cycloaddition reactions. Recently, the 'linker' property of 1,2,3-triazoles was demonstrated, and a novel class of 1,2,3-triazole-containing hybrids and conjugates was synthesised and evaluated as lead compounds for diverse biological targets. These lead compounds have been demonstrated as anticancer, antimicrobial, anti-tubercular, antiviral, antidiabetic, antimalarial, anti-leishmanial, and neuroprotective agents. The present review summarises advances in lead compounds of 1,2,3-triazole-containing hybrids, conjugates, and their related heterocycles in medicinal chemistry published in 2018. This review will be useful to scientists in research fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology.
PMID: 31300317 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry - July 3, 2019 Category: Chemistry Authors: Bozorov K, Zhao J, Aisa HA Tags: Bioorg Med Chem Source Type: research