Surface-modified nanocrystalline cellulose from oil palm empty fruit bunch for effective binding of curcumin.

Surface-modified nanocrystalline cellulose from oil palm empty fruit bunch for effective binding of curcumin. Int J Biol Macromol. 2019 Jul 10;: Authors: Foo M, Tan C, Lim P, Ooi EC, Tan K, Chew IM Abstract Rod-shape particles appeared to have long circulatory time, tumor accumulation and high cellular uptake as drug carrier. Acid hydrolysed nanocrystalline cellulose (NCC) from empty fruit bunch exhibits a width of 13-30 nm and length of 150-360 nm in rod-shape structure, holds good potential for high level of drug loading. Moreover, NCC is particularly superior as a favorable bio-based carrier owing to its biodegradability and biocompatibility. The Fourier-transform infrared spectroscopy results confirmed the binding of curcumin on the modified NCC with notable spectra changes caused by tannic acid (TA) and decylamine (DA) modification. TA-DA modification rendered NCC with a higher level of hydrophobicity, as evidenced by a substantial increase contact angle from 45° to 73° via contact angle analysis. TA-DA tailored NCC with a binding efficiency in the range of 95-99% was confirmed by UV-vis spectrometer, which is at least twofold higher than unmodified NCC at any curcumin concentration tested. This remarkable binding is comparable with commercialized NCC of wood-based origin. This work suggests NCC a superior and sustainable material as water-insoluble drug carrier, while TA-DA modification indicated a promising approach to a...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research